PEDIATRIC LUNG & HEART COMPLICATIONS OF HIV INFECTION

该计划的主要目标是进一步了解艾滋病毒 婴幼儿感染及其对心脏疾病的影响 还有肺。为此，我们将： 1.收集有关产前病程和随后的肺部疾病的信息 第一组：婴儿和儿童心脏生长、发育和功能 最近被诊断为经围产期传播的有症状的艾滋病毒感染； 感染艾滋病毒母亲的新生儿；母亲的新生儿 HIV感染血清呈阴性但感染风险较高的 艾滋病病毒 2.确定肺和其他疾病的类型、发生率、病程和转归。 这些儿童的心血管疾病并阐明其病因 以及这些肺和心脏异常的病理生理学。 该程序分为三个作用域： 1.临床及化验--招募所需数目的病人； 协调临床护理与本提案中概述的各种研究，并 为传染病和免疫学提供核心实验室支持 这项调查的组成部分。 2.心脏病学--确定#年心脏病的自然病史 儿童HIV感染及其原发和继发发病率 围产期HIV感染儿童的心脏病；早期识别 感染儿童心脏病的临床标记物；测定 导致临床疾病的实验室标志物和辅助因素 被感染的病人。 3.肺--研究中国人肺部疾病的自然病史 感染艾滋病毒的婴儿和儿童在宫内或 在围产期；收集有关关系的信息 HIV感染与随后的肺部生长、发育和 功能；研究病毒的作用；识别可能有助于 早期诊断和治疗。

The primary objective of the program is to further understand HIV infection in infants and children and its effects on disorders of the heart and lung. To this end we will: 1. collect information on the prenatal course and subsequent pulmonary cardiac growth, development and function of Group I: Infants and children with recently diagnosed, perinatally transmitted symptomatic HIV infection; Newborn infants of mothers infected with HIV; Newborn infants of mothers who are seronegative for HIV infection but at high risk of infection for HIV 2. determine the types, incidence, course, and outcome of pulmonary and Cardiovascular disorders in these children and to elucidate the etiology and pathophysiology of these lung and heart abnormalities. The program is separated into three scopes: 1. Clinical and Laboratory - To recruit the required number of patients; coordinate clinical care with various studies outlined in this proposal and to provide core laboratory support for infectious and immunological components of this investigation. 2. Cardiology - To determine the natural history of cardiac disease in children with HIV infection and the incidence of both primary and secondary cardiac disease in children with perinatal HIV infection; identify early clinical marker of cardiac disease in infected children; determine laboratory markers and co-factors which precipitate clinical disease in infected patients. 3. Pulmonary - To study the natural history of pulmonary disorders in infants and children infected with HIV transmitted either in utero or during the perinatal period; collect information on the relationship between HIV infection and subsequent pulmonary growth, development and function; study the role of viruses; to identify tests that might aid in early diagnosis and treatment.