LONG TERM FOLLOW UP OF THE NIDDK LTD

描述：(改编自调查人员摘要)NIDDK肝脏 移植数据库(LTD)是一个拥有1500多个注册中心的多中心注册中心 连续的肝移植(LT)候选人，在 1990年和1994年，由美国三大肝脏移植中心 各州。因此，它是唯一科学地设计和实施的 从多中心研究中得出大量LT队列的近期经验 可以对这个国家的候选人和接受者进行严格的分析。这个 努力建立这一详细和高质量的资源 根据一份为期7年的NIDDK合同，合同将于1997年12月结束。有价值的 本研究收集的信息包括临床和实验室数据。 按协议和在事件发生时收集，并丰富了 从高比例的接受者，一系列的银行 血清样本和虚拟组织库。由于目前的合同 只提供了平均3年的随访，主题的范围 可以使用这个全面的数据库进行调查的是 有限的。目前的计划是继续对以下队列进行后续行动 移植受者将在下一阶段再接受5年 移植后时期，原发疾病复发和 免疫抑制和再次移植的长期不良反应是 最有可能发生的事情。因此，协调中心在以下机构的支持下 三个有限公司临床中心的调查人员将能够 获得平均10年(8-12年)至 观察检查前、检查期间和检查后记录的信息 移植。预计拟议的努力将产生巨大的成果 可能直接影响未来的科学和临床重要性 移植候选者的选择与移植后患者 管理层。

DESCRIPTION: (Adapted from Investigator's abstract) The NIDDK Liver Transplantation Database (LTD) is a multicenter registry of more than 1500 consecutive candidates for liver transplantation (LT), recruited between 1990 and 1994, by three major liver transplant centers in the United States. As such, it is the only scientifically designed and implemented multicenter study from which the recent experience of a large cohort of LT candidates and recipients in this country can be rigorously analyzed. The effort to build this detailed and high quality resource was carried out under a 7-year NIDDK contract which ends in December 1997. Valuable information collected in this study includes clinical and laboratory data collected by protocol and at a time of events, and it is enriched with protocol biopsies from a high proportion of recipients, a bank of serial serum specimens, and a virtual tissue bank. Since the current contract only provided for follow-up of 3 years on average, the range of topics that could be investigated, using this comprehensive data base, is limited. The current plan is to continue the follow-up of the cohort of transplant recipients for another 5 years through the next phase of the post-transplantation period, when recurrence of the original disease and long-term adverse effects of immunosuppression and re-transplantation are most likely to occur. Thus, the Coordinating Center, with the support of the investigators of the three LTD clinical centers, will be able to obtain complete follow-up for an average of 10 years (8-12 years) to observe the information recorded in the study before, during an dafter transplantation. The proposed effort is expected to yield results of great scientific and clinical importance which could directly influence future transplant candidate selection and post-transplantation patient management.