STRESS AND AGING; MECHANISMS, MODELS AND INTERVENTIONS

该提案要求为2000年6月2日至5日在特雷蒙波士顿旅馆和马萨诸塞州波士顿塔夫茨大学的美国农业部老龄问题人类营养研究中心举行的美国老龄问题协会第29届年会的发言人提供一年的旅费和住宿费支助。 本次会议的重点是“老龄化的压力：机制，模型和干预。“对衰老和年龄相关疾病中压力参与的关注将包括氧化和环境压力方面，针对潜在机制的研讨会，动物和体外模型，以及旨在改善年龄相关压力负面影响的干预措施，例如，热量限制和营养方案。 这些主题包含了老年医学的不同领域，这些领域在研究和公共社区中受到越来越多的关注，因此将吸引具有不同背景和对老龄化有共同兴趣的科学家。 会议由六个专题讨论会组成：I线粒体参与氧化应激和衰老的机制; II氧化应激的细胞影响; III氧化应激和神经变性; IV抗氧化剂和干预; V生理应激的综合反应; VI应激反应的分子表征。 除了六个专题讨论会之外，6月2日还将举行一个名为“衰老研究中的DNA微阵列”的会前研讨会。“研讨会将为资深研究人员和学生提供一个机会，了解这种令人兴奋的方法，重要的技术考虑及其应用于生物学许多领域的可能性。 最后，6月5日，塔夫茨大学人类营养研究中心将主办一个题为“衰老和肥胖相关疾病的饮食干预”的研讨会。

The proposal requests the single-year support of travel and lodging expenses for speakers at the 29th annual American Aging Association (AGE) meeting being held June 2 - 5, 2000, at the Tremont Boston hotel and the Jean Mayer United States Department of Agriculture (USDA) Human Nutrition Research Center on Aging at Tufts University in Boston, Massachusetts. The emphasis of this meeting is "Stress in Aging: Mechanisms, Models and Interventions." The focus on the involvement of stress in aging and age-related diseases will include aspects of both oxidative and environmental stresses with symposia directed at potential mechanisms, animal and in vitro models, and interventions aimed at ameliorating the negative impact of age-related stresses, e.g., caloric restriction and nutritional regimens. These topics incorporate diverse areas of biogerontology which are receiving increasing attention in the research and public communities and will, therefore, attract scientists with divergent backgrounds and a common interest in aging. The meeting consists of six symposia: I Mechanisms of Mitochondrial Involvement in Oxidative Stress and Aging; II Cellular Impact of Oxidative Stress; III Oxidative Stress and Neurodegeneration; IV Antioxidants and Interventions; V Integrated Responses to Physiological Stress; VI Molecular Characterization of the Stress Response. In addition to the six symposia, there will be a preconference workshop on June 2nd entitled, "DNA Microarrays in the Study of Aging." The workshop will provide an opportunity for both established researchers and students to learn about this exciting methodology, important technical considerations and the possibilities for its application to many areas of biogerontology. Lastly, a symposium entitled, "Dietary Interventions in Aging and Age-Associated Disease" will be sponsored by the Human Nutrition Research Center on Aging at Tufts University on June 5th.