Defining a new mechanism of blood pressure regulation and its role during sepsis

血压失调是死亡的主要原因，因为它与心血管疾病和脓毒症的病理学有关。因此，重要的是我们要提高我们对血压是如何调节的理解，以便为患者提供有效的治疗。在这项研究中，我们的目标是探索一种新发现的机制，可能解释感染如何导致血压变化。这是通过激活名为cGAS的细胞DNA传感器实现的。一旦被来自细菌或病毒的DNA激活，这种蛋白质就会产生一种名为cGAMP的小分子，我们发现它可以通过一种新的过程介导血管舒张和降低血压。本研究的目的是进一步研究这一新的过程及其在调节血压中的作用，以及在脓毒症的基础病理学中的作用。在这里，它预计，研究结果提供了更深入的了解血压是如何调节的，以及新的治疗目标。

Dysregulation in blood pressure is a leading cause of mortality as it is causatively associated with cardiovascular disease and the pathology that underlies sepsis. Therefore, it is important that we improve our understanding of how blood pressure is regulated, so that patients can be provided with effective therapy. In this study we aim to explore a newly identified mechanism that is likely to explain how infection can lead to changes in blood pressure. This is through the activation of a cellular DNA sensor named cGAS. Once activated by DNA derived from bacteria or viruses this protein generates a small molecule called cGAMP, which we have discovered can mediate vessel relaxation and lowering of blood pressure through a novel process. The aim of this study is to further investigate this new process and its role in regulating blood pressure, as well as in the underlying pathology of sepsis. Here it anticipated that findings with provide greater insight into how blood pressure is regulated, as well as new targets for therapy.