Stochastic mathematical modelling of the Wnt signalling pathway.

Wnt信号通路在多细胞生物体中起关键作用，调节细胞的增殖、凋亡和迁移等过程。错误的Wnt信号与退行性疾病、发育障碍和癌症有关，因此是治疗药物的潜在靶点。该项目将对WNT信号通路进行随机空间模拟，并将其与实验数据相匹配。该模型将被扩展到与细胞周期相结合。肿瘤的增殖增加与Wnt组分的突变有关。利用扩展的模型，可以预测Wnt靶向治疗癌症药物对癌细胞增殖率的影响，并与实验进行比较。

The Wnt signalling pathway is pivotal in multicellular organisms, regulating cellular processes such as proliferation, apoptosis and migration. Faulty Wnt signalling is associated with degenerative diseases, developmental disorders and cancers and is therefore a potential target for therapeutic drugs. This project will perform a stochastic spatial simulation of the Wnt signalling pathway which will be matched to experimental data. The model will be extended to integrate with the cell cycle. Increased proliferation in tumours has been linked to mutations in Wnt components. Using the extended model, the effect of Wnt-targeting therapeutic cancer drugs on cancer cell proliferation rates will be predicted and compared to experiments.