MRI AND RT PA TREATMENT OF EMBOLIC STROKE

描述(改编自申请者摘要)：此申请将开发 预测溶栓疗效的磁共振成像(MRI)标准 大鼠局灶性脑缺血后。这项提议的目标是 评估MRI测量是否可以识别可逆性损伤的组织和 确定在接受治疗时注定要出血的脑组织 溶栓剂。申请者还将调查是否有疗效 可以用定量的方法来表征和预测溶栓干预的 MRI可测量参数的变化。提出了两个具体目标：具体 目的1-预测栓塞性卒中后的出血性转化(HT) 核磁共振在大鼠溶栓实验中的应用。具体目标2a--确定可逆转的损害 大鼠栓塞性卒中及溶栓后缺血组织的MRI研究。 特异靶2b B确定MRI预测急性脑出血疗效的能力 用rt-PA进行溶栓干预。申请者将采用多种模式 结合组织学终点的MRI和图像分析方法 栓塞性卒中的脑组织特征及预测 溶栓治疗的结果。长期目标是提供新的和 与急性中风的治疗相关的重要信息 溶栓治疗。

DESCRIPTION (Adapted from Applicant's Abstract): This application will develop magnetic resonance imaging (MRI) criteria to predict outcome of thrombolysis after focal cerebral embolic ischemia in rats. The goal of this proposal is to assess whether the MRI measurements can identify reversibly damaged tissue and identify cerebral tissue that is destined to hemorrhage when treated with a thrombolytic agent. The applicants would also investigate whether the efficacy of thrombolytic intervention can be characterized and predicted by quantitative changes in MRI measurable parameters. Two specific aims are proposed: Specific Aim 1-To predict hemorrhagic transformation (HT) after embolic stroke and thrombolysis in rats using MRI. Specific Aim 2a-To identify reversibly damaged ischemic tissue after embolic stroke and thrombolysis in rat using MRI. Specific Aim 2b B To determine the ability of MRI to predict the efficacy of thrombolytic intervention with rt-PA. The applicants would employ multimodality MRI and image analysis methodology in combination with histological endpoints to characterize cerebral tissue subjected to embolic stroke and to predict outcome of thrombolytic therapy. The long-term goal is to provide new and important information relevant to the treatment of acute stroke by thrombolysis.