EYE/HAND COORDINATION BY CEREBELLAR OUTPUT NEURONS

我们的长期目标是了解小脑在大脑中的作用。 控制伸手去抓住一个物体。抓住一个物体的范围是 日常活动中使用的基本运动和协调的生产 伸手抓握高度依赖于小脑功能。分析 小脑的参与，达到把握将导致更好的 了解或组织整个电机系统，并可能 为设计假体装置提供了有价值的指导， 补偿受损的电机控制。 我们已经发现小脑回路专门用于 控制伸手去抓。前肢的简单运动 激活小脑回路，但协调的行动， 抓到的东西会加快神经放电的速度。我们还发现 小脑的区域专门负责控制特定的 要掌握的范围的组成部分。肢体相关小脑输出神经元 仅参与抓取部件的控制，而不参与 运动的一部分。 为了准确地实现其行为目标，抓取- 相关的控制信号需要与视觉信息相结合 关于物体的空间位置和外部特征， 抓住了这需要眼睛和肢体之间的精确协调- 相关神经网络构成以下理论基础的工作假设 提出的实验是，小脑是一个关键的组成部分， 这种协调背后的神经基质。具体而言是 实验将检验眼球运动相关的小脑输出 神经元位于腹外侧的后间位和邻近 腹侧齿状核的部分提供与肢体相关的神经网络， 关于要抓取的目标的空间位置的信息 这对河段的运输组成部分至关重要， 准确

Our long-range goal is to understand the role of the cerebellum in the control of reaching to grasp an object. The reach to grasp an object is a basic movement used in daily activities and production of a coordinated reach to grasp is highly dependent upon cerebellar function. Analyzing cerebellar participation in the reach to grasp will lead to much better understanding or the organization of the entire motor system and may provide valuable guidance to the design of prosthetic devices attempted to compensate for impaired motor control. We have discovered that cerebellar circuitry is specialized for the control of a reach to grasp. Simple movements of the forelimb do not activate cerebellar circuitry, but the coordinated action of reaching and grasping elicits high rates of neural discharge. We have also discovered that regions of the cerebellum are specialized for the control of specific components of the reach to grasp. Limb-related cerebellar output neurons only participate in the control of the grasping component and not the transport component of the movement. For a reach to grasp to accurately accomplish its behavioral goal, gras- related control signals need to be integrated with visual information concerning the spatial location and external features of the object to be grasped. This requires precise coordination between eye-related and limb- related neural networks. The working hypothesis that forms the basis for the proposed experiments is that the cerebellum is a critical part of the neural substrate underlying such coordination. Specifically, the experiments will test the idea that eye movement-relate cerebellar output neurons located ventrolaterally in posterior interpositus and adjacent parts of ventral dentate nucleus provide limb-related neural networks with information concerning the spatial location of the target to be grasped that is critical for the transport component of the reach to grasp to be accurate.