ENDOSCOPE BASED B-SCAN SCANNING ACOUSTIC MICROSCOPE

描述：（改编自申请人摘要）：目前进行组织学诊断的方法是切除活检。活检的一个主要限制是抽样误差。除非存在离散的肿块，否则活检的位置是任意选择的，因此异常病理可能不会出现在样本中。为了解决这个问题，PI建议开发一种安装在内窥镜、心导管或腹腔镜尖端的声学显微镜，这将允许对细胞进行原位成像。这将允许在没有活检或选择性靶向活检的情况下进行组织学诊断。声学显微镜的潜在临床应用包括对巴雷特食管等癌前病变的原位成像、食管和胃肠道其他部位早期恶性肿瘤的检测以及心肌病理的可视化。初步实验表明，200兆赫的换能器在成像细胞所需的分辨率和超声穿透深度之间提供了最佳的权衡。PI建议在内窥镜的尖端安装一个200mhz的扫描声学显微镜。换能器将由氧化锌制成，氧化锌将通过反应溅射沉积。超声波电机将用于扫描换能器以生成b扫描图像。拟议的商业应用：基于内窥镜的声学显微镜的拟议商业应用是筛查早期恶性肿瘤，如巴雷特食管。

DESCRIPTION: (Adapted from the Applicant's Abstract): The current method of making a histological diagnosis is excisional biopsy. A major limitation of biopsy is sampling error. Unless a discrete mass is present, the site of biopsy is arbitrarily chosen so that the abnormal pathology may not be present in the sample. To circumvent this problem, the PI proposes to develop an acoustic microscope mounted at the tip of an endoscope, cardiac catheter or laparoscope, which will permit in situ imaging of cells. This will permit making a histological diagnosis without biopsy or alternatively targeted biopsy is feasible. Potential clinical applications of acoustic microscopy include in situ imaging of premalignant conditions such as Barrett's esophagus, detection of early malignancy in the esophagus and other parts of the gastrointestinal tract and visualization of myocardial pathology. Preliminary experiments indicate a 200 MHz transducer which provides an optimal trade-off between the resolution required for imaging cells and the depth of penetration of ultrasound. The PI proposes to construct a 200 MHz scanning acoustic microscope mounted at the tip of an endoscope. The transducer will be made of zinc oxide that will be deposited by reactive sputtering. An ultrasonic motor will be used to scan the transducer to generate a B-scan image. PROPOSED COMMERCIAL APPLICATION: The proposed commercial application of the endoscope based acoustic microscope is screening for early malignancy in conditions such as Barrett's esophagus.