THE ECONOMICS OF POLYDRUG ABUSE

描述：(申请人摘要) 这一新的应用涉及到使用行为经济学来分析 多药滥用。两组5只恒河猴将用于平行研究 多药滥用的证据。一组猴子将有机会获得冰毒和 另一组将获得美沙酮。药品的运送将是 这取决于固定比率时间表的完成情况。在固定比例下 增强剂的计划交付取决于制造固定数量的 回应。在本申请中，固定比率时间表的完成将 结果产生了0.67毫升的液体。取决于实验结果 条件下，液体会是水或药物的溶液。双液输送 系统将会出现，从而让猴子可以在液体之间进行选择。在……里面 研究1，甲基苯丙胺与水的溶液，或 美沙酮VS水将会出现。药物溶液的浓度 将有所不同，以及所需的响应数量(即固定比率大小 每种液体的输送也将有系统地改变。结果将是 以不同价格(即 固定比例大小和药物浓度的组合)。在下一组 研究将分析一系列药物对，因为一种药物的价格是 更改为不同的值，而另一种药物的价格保持不变。 在这些研究中，猴子将可以选择服用两种药物或 一种药或者两种都不用。重点是药物摄取之间的相互作用。 以及他们的价格。总体目标是确定哪些药物组合 是在每种药物的价格不同时服用的。结果将证明 分析多种药物滥用的系统和量化战略。

DESCRIPTION: (Applicant's Abstract) This new application concerns the use of behavioral economics to analyze polydrug abuse. Two groups of 5 rhesus monkeys will be used in parallel studies of polydrug abuse. One group of monkeys will have access to methamphetamine and the other group will have access to methadone. The delivery of drugs will be contingent upon the completion of fixed-ratio schedules. Under a fixed-ratio schedule delivery of the reinforcer is contingent upon making a fixed-number of responses. In the present application completion of fixed-ratio schedules will result in the delivery of 0.67 ml of liquid. Depending upon the experimental conditions, the liquid will be water or a solution of drug. Two liquid delivery systems will be present thereby giving the monkey a choice between liquids. In Study 1, either a solution of methamphetamine vs. water, or a solution of methadone vs. water will be present. The concentration of the drug solutions will be varied and also the number of response (i.e. fixed-ratio size) required per liquid delivery will also be systematically changed. The results will be plotted in terms of the drug amount consumed at different prices (i.e combinations of fixed-ratio size and drug concentration). In the next set of studies a series of drug pairs will be analyzed as the price for one drug is changed to different values and the price of the other drug is held constant. In these studies the monkeys will have the option of taking two drugs or just one drug or neither. The focus is on the interactions between intake of drug and their prices. The overall aim is to determine what combinations of drugs are taken when the cost of each drug is varied. The results will demonstrate a systematic and quantitative strategy for the analysis of polydrug abuse.