PLACENTA--IMPLANTATION TO DELIVERY

描述（改编自申请人的描述）：目的 会议，“第14届罗切斯特滋养层会议”是提供一个论坛 介绍和讨论新的分子，生物化学，细胞， 以及与人类生殖的许多方面相关的临床研究，包括 发育、遗传、传染病，特别是艾滋病毒、毒理学 和免疫学方面。本次会议的长期目标是促进 预期可导致人类生育能力提高的相互作用 减少儿童艾滋病毒感染、胎儿流产、 重要的妊娠期疾病的发病率，如早产， 胎膜、胎儿生长迟缓和先兆子痫 高血压此外，科学家与 早孕调查学会联合举行的会议 有望为疾病机制带来新的见解。 重点研究的具体领域是：1）胚泡和胎盘的遗传调控 2）子宫内HIV感染和合并感染的机制 3)必需激素和生长因子/细胞因子的分子调节 促进怀孕，4）调节血管供应和 这在疾病中，5）炎症细胞和妊娠损失的关系， 存活率，6）妊娠丢失中的生长因子网络，7）组成和 生殖组织中的免疫细胞类型，8）胎盘表达 主要组织相容性基因，9）细胞防御机制， 环境毒物，特别是氧化应激的作用和10）影响 胎儿健康对成人结果的影响该格式旨在整合最近的 基础和临床研究的成果。会议将于4-8日举行 2000年10月 目前正在寻求基金会和私营部门提供更多的支助。 公司。 本申请的目的是寻求资金支持 为20名年轻调查员和受训人员提供部分资金， 介绍他们的研究。

DESCRIPTION (Adapted from applicant's description): The objective of the Conference, "The 14th Rochester Trophoblast Conference" is to provide a forum for the presentation and discussion of new molecular, biochemical, cellular, and clinical studies relevant to many aspects of human reproduction, including developmental, genetic, infectious disease, in particular HIV, toxicological and immunological aspects. The long range goal of this Conference is to foster interactions that could be expected to lead to improvements in human fertility and reduction in HIV infection in children, fetal wastage, reduction in the incidence of important gestational diseases such as premature rupture of membranes, fetal growth retardation, and pre-eclampsialpregnancy-induced hypertension. Additionally, interaction of scientists with those of the jointly held meeting of the Society for the Investigation of Early Pregnancy would be anticipated to lead to new insights into mechanisms of disease. Specific areas of focus are: 1) genetic regulation of blastocyst and placental development, 2) mechanisms of HIV infection and co-infection in utero 3) molecular regulation of essential hormones and growth factors/cytokines which foster pregnancy, 4) regulation of vascular supply and abnormalities of this in disease, 5) relation of inflammatory cells and pregnancy loss on survival, 6) growth factor networks in pregnancy loss, 7) composition and types of immune cells in reproductive tissues, 8) placental expression of major histocompatibility genes, 9) mechanisms of cellular defense against environmental toxicants, especially role of oxidant stress and 10) the effect of fetal health on adult outcomes. The format is designed to integrate recent findings in basic and clinical research. The meeting will be held from 4-8 October 2000. Major additional support is being sought from foundations and private corporations. The purpose of this application is to seek funding to support partial funding for 20 young investigators and trainees to both attend and present their research.