QUANTITATIVE IMAGING OF CEREBRAL BLOOD FLOW AND OXYGEN CONSUMPTION

这个项目的主要目的是开发新的磁共振(Mr)。 用于对人类脑血流(CBF)进行成像的“自旋标记”方法， 并将这些方法应用于生理学和药理学研究 精神病患者的功能障碍。新的磁共振方法使用经典的 示踪理论建立在Kty-Schmidt方程的基础上，但没有使用 放射性示踪剂他们使用稳定的微扰磁自旋态 同位素。该项目之前的工作确定了一些主要的 妨碍脑血定量计算的问题 人体内的流动价值，并发展了理论方法论途径 克服了这些问题。 在过去的一年中，CBF成像方法得到了验证 MR/PET联合研究，并已应用于研究区域增长 在脑血流中的运动和认知激活范式。为 例如，初级感觉运动皮质中CBF的平均增加 运动任务为60+-10毫升/100g/分钟(91%)，而 工作记忆任务中前额叶皮质脑血流量为22+/-5 CC/100g/min(23%)。未来两年的工作重点将放在研究上 精神病人的局部脑功能障碍。

The major aim of this project is to develop new magnetic resonance (MR) "spin tagging" approaches for imaging cerebral blood flow (CBF) in humans, and to apply these approaches to study physiological and pharmacological dysfunction in psychiatric patients. The new MR approaches use classical tracer theory based on the Kety-Schmidt equation, but instead of using radioactive tracers they use perturbed magnetic spin states of stable isotopes. Previous work in this project identified a number of major problems that had precluded the calculation of quantitative cerebral blood flow values in humans, and developed theoretical methodological approaches for overcoming these problems. During the last year the CBF imaging approaches have been validated using a combined MR/PET study, and have been applied to study regional increases in cerebral blood flow in motor and cognitive activation paradigms. For example, the average increase in CBF in primary sensorimoter cortex during motor tasks was 60 + - 10 cc/100g/min (91%), while the average increase in CBF in prefrontal cortex during working memory tasks was 22 +/- 5 cc/100g/min (23%). Work in the upcoming two years will focus on the study of regional cerebral dysfunction in psychiatric patients.