INTEGRATION OF MULTIDISCIPLINARY SENSORY DATA

描述(改编自申请人的摘要)：主要目的是 项目是开发一个全面的嗅觉通路模型，如 感官处理的基本步骤的范例。模型将是 基于由多学科实验组成的共享数据库 来自分子生物学、神经解剖学、电生理学和 药理学。目标将是使用这些数据来构建 处理过程中涉及的基本步骤的划分模型 感觉通路，包括感觉转导，形成 地形图、模块单元的功能和操作 突触微电路，并将其用作网络的基础 整个系统的模型。使技术能够有效地 将不同的实验室群互联并增强其 在三个层面上需要格式化和交换数据的能力：(1)数据 目前致力于类似研究的不同实验室之间的交流 问题；(2)格式化和整合来自不同学科的数据 共享数据库；以及(3)共享数据库的新格式 相关的集成工具，可促进更高效的数据 交换和模型构建。使能技术涉及三个方面 联网小组：首席调查员的核心实验室； 将他的实验室与耶鲁大学的几个实验室联系在一起的局域网； 远程电子协作和合作者。一个主要组成部分 这个项目的核心是一个公认的中心的密切合作 耶鲁大学的信息学研究。

DESCRIPTION (Adapted from applicant's abstract): The major aim of the project is to develop a comprehensive model of the olfactory pathway as a paradigm for basic steps in sensory processing. The model will be based on a shared database consisting of multidisciplinary experimental data from molecular biology, neuroanatomy, electrophysiology, and pharmacology. The goal will be to use this data to construct compartmental models of the fundamental steps involved in processing in the sensory pathway, including sensory transduction, the formation of topographical maps, the functions of modular units, and the operations of synaptic microcircuits, and to use these as the basis for a network model of the entire system. Enabling technologies for effectively interconnecting a diverse group of laboratories and enhancing their ability to format and exchange data are needed at three levels: (1) data exchange between different laboratories currently working on similar problems; (2) formatting and integrating data from different disciplines into a shared database; and (3) new formats for the shared database and associated integrative tools that will facilitate more efficient data exchange and model construction.The enabling technologies involve three networked groups: the core laboratory of the principal investigator; local area nets that tie his laboratory to several Yale laboratories; and distant electronic collaborations and collaborators. A major component of this project is the close collaboration of a recognized center for informatics research at Yale.