AGING EFFECTS ON CARDIOVASCULAR FUNCTION

描述(改编自申请人的摘要)：三个缺陷 已经观察到随着年龄的增长，血管僵硬增加，抑郁 对儿茶酚胺的反应性和心脏功能受抑。 肾上腺素能信号的紊乱可能预示心脏功能障碍 以及衰老过程中诱导的血管系统。一共有三个 这项研究的主要组成部分：1)改变了肾上腺素能控制 在老年血管系统中，血管活性先于僵硬的增加；2) 左心室(LV)功能的肾上腺素能控制改变预示 老年心脏左心功能下降；3)心脏和心脏功能的改变 老化心脏中的血管结构是导致血管改变的原因 和左心室功能，但这些变化不是肾上腺素能改变所必需的 发信号。为了解决这些成分，动脉的变化 压力/尺寸关系、左心室功能与肾上腺素能信号的改变 随着年龄的增长将在意识中决定，在长期的仪器中 猴子。衰老在细胞和分子水平上的变化以及 心脏和血管结构的组织学改变将被检查。 这些研究将在4组猴子身上进行：1)较年轻的成年猴子 (3-5岁)；2)成年(7-10岁)；3)老年人(15-19岁)； 4)老年人(20岁以上)。

DESCRIPTION (adapted from the applicant's abstract): Three defects which have been observed with aging are increased vascular stiffness, depressed responsiveness to catecholamines, and depressed cardiac function. Derangements in adrenergic signaling may presage dysfunction in the cardiac and vascular systems that is induced by the aging process. There are three major components to this study: 1) that altered adrenergic control of vasoactivity precedes increased stiffness in the aged vasculature; 2) that altered adrenergic control of left ventricular (LV) function presages the decline in LV function in the aged heart; and 3) that changes in cardiac and vascular structure in the aging heart are responsible for altered vascular and LV function, but these changes are not necessary for altered adrenergic signaling. To address these components the alterations in arterial pressure/dimension relations, LV function and altered adrenergic signaling with aging will be determined in conscious, chronically instrumented monkeys. The alterations in aging at the cellular and molecular level and histologic alterations in cardiac and vascular structure will be examined. These studies will be conducted in 4 groups of monkeys: 1) younger adults (3-5 years); 2) mature adults (7-10 years); 3) older adults (15-19 years); and 4) senescent adults (older that 20 years).