STUDIES ON ACCEPTABILITY OF VAGINAL MICROBICIDES

说明（根据申请人的说明改编）： 南非流行病呼吁该国采取紧急措施预防艾滋病毒。 来自两个国家（约翰内斯堡和德班）的多学科研究人员小组 和两个国际网站（英国和美国）提出了一系列创新的研究， 确定杀菌剂的可接受性。申请人的丰富经验 在进行临床、行为、药学、社会、生物统计学、流行病学 和卫生系统研究使他们处于独特的地位，可以进行广泛的 研究来评估可接受性。研究目标将在五个 采用定性和定量相结合的方法。目标 有：1.回顾性评估与持续使用a 在参加了第三阶段试验的性工作者中使用阴道杀菌剂; 2.制定衡量可接受性的标准化工具; 3.持续使用阴道给药相关因素的前瞻性评估 非临床环境中的杀微生物剂（如果有适当的产品）; 4.确定可接受的产品特性和输送机制 使用惰性产品的杀微生物剂以及这些发现在评估 目前正在开发的几种产品的可接受性; 5.识别 在卫生保健部门采用和使用杀微生物剂的促进因素和障碍 南非的护理提供者和潜在用户。

DESCRIPTION (Adapted from the applicant's description): The explosive nature of the South African epidemic calls for urgent measures for HIV prevention in the country. The multidisciplinary group of researchers from two National (Johannesburg and Durban) and two International sites (UK and USA) propose a series of innovative studies of determining acceptability of microbicides. The extensive experience of the applicants in conducting clinical, behavioral, pharmaceutical, social, biostatistics, epidemiological and health systems research places them in a unique position to conduct a wide range of studies to assess acceptability. The research objectives will be addressed in five phases with a combination of qualitative and quantitative methods. Objectives include: 1. Retrospective assessment of factors associated with continued use of a vaginal microbicide among sex workers who had participated in a Phase III trial; 2. Development of a standardized tool for measuring acceptability; 3. Prospective assessment of factors associated with continued use of a vaginal microbicide in a non-clinical setting (if appropriate products are available); 4. Ascertainment of acceptable product characteristics and delivery mechanisms for microbicides using inert products and application of these findings to assessing the acceptability of several products currently in development; and 5. Identification of facilitators and barriers to the introduction and use of microbicides among health care providers and potential users in South Africa.