THERAPY DEVELOPMENT FOR MENTALLY ILL DRUG ABUSERS

描述：(申请人摘要) 此应用程序请求获得独立科学家奖(K02)的支持 凯特·凯里博士，并介绍了申请者的研究和职业生涯 发展计划。申请人以前和现在由NIDA资助的研究 重点关注严重和顽固性精神病患者的药物使用和滥用 门诊部。她的职业目标包括(A)获得开发方面的专业知识 增强变革动力的疗法，(B)指导治疗结果 研究，以及(C)指导初级科学家。该提案描述了以下两项 三个目前得到资助的项目。项目1是由NIMH资助的一项正在进行的研究 正在评估两种预防措施对成人糖尿病的疗效 严重的精神疾病。参与者被随机分配到一种药物使用中 减少组，艾滋病毒风险降低组，或仅标准治疗 组，全部设计为门诊精神治疗的补充。两者都有 小组在5周内进行10次会议，并纳入教育， 激励增强和行为技能的组成部分。参与者 完成基线、治疗后、3个月和6个月的随访评估。 项目2是由NIDA资助的第一阶段治疗开发项目。此顺序 研究计划包括：(A)心理测量学研究，以确定 足够可靠和有效，可作为结果的衡量标准；和(B) 开发和初步试点测试一个附加模块，旨在增强 门诊精神分裂症和药物使用障碍患者参与的意愿 药物治疗。未来的计划包括继续治疗开发过程 从项目2开始，采用更复杂的设计，优化长期 激励干预的有效性--辅以 以技能为基础的治疗，并确定应答者和 无回应者。申请人的职业发展计划侧重于活动 旨在促进高级地位和领导力的持续进步 在战场上。这些措施包括通过课程和 与领先的治疗开发中心进行咨询；与 富有成效的当地同事小组；进行方案研究；以及 为初级科学家提供研究指导。这一奖项将允许 申请者受保护的时间(教学救济和暑期支持)，以继续 发展她在治疗严重药物滥用人群中的研究 精神有问题。

DESCRIPTION: (Applicant's Abstract) This application requests support for an Independent Scientist Award (K02) for Kate Carey, Ph.D., and describes the applicant's research and career development plans. The applicant's previous and current NIDA-funded research focuses on substance use and abuse among severely and persistently mentally ill outpatients. Her career goals include (a) acquiring expertise in developing therapies that enhance motivation for change, (b) conducting treatment outcome research, and (c) mentoring junior scientists. This proposal describes two of three currently funded projects. Project 1 is an ongoing NIMH-funded study that is evaluating the efficacy of two prevention interventions for adults with severe mental illness. Participants are randomly assigned to a substance use reduction group, a HIV risk reduction group, or a standard treatment only group, all designed as supplements to outpatient psychiatric treatment. Both groups run for 10 sessions over 5 weeks, and incorporate education, motivational enhancement and behavioral skills components. Participants complete baseline, post-treatment, 3-month and 6-month follow-up assessments. Project 2 is a NIDA-funded Phase I therapy development project. This sequential research plan includes (a) psychometric research to identify measures that are sufficiently reliable and valid to serve as measures of outcome, and (b) the development and initial pilot testing of an add-on module designed to enhance readiness of outpatients with schizophrenia and drug use disorders to engage in drug treatment. Future plans involve continuing the therapy development process started in Project 2 with more sophisticated designs, optimizing the long-term effectiveness of motivational interventions by supplementing them with skills-based therapies, and identifying characteristics of responders and non-responders. The applicant's career development plans focus on activities designed to facilitate continued progress toward senior status and leadership in the field. These include continued skill development through courses and consultation with leading therapy development centers; collaboration with a productive group of local colleagues; conducting programmatic research; and providing research mentoring to junior scientists. This award would allow the applicant protected time (teaching relief and summer support) to continue to develop her research on the treatment of substance abuse among the severely mentally ill.