RESEARCH TRAINING IN JUVENILE BIPOLAR DISORDER

描述（改编自申请人的摘要）：建议的指导 科学家发展奖为新的少数民族教师概述了一个计划， 职业发展和研究精神药理学和神经影像学 青少年躁郁症 该计划的重点将是临床 在一组儿童中进行的情绪稳定剂（双丙戊酸钠）试验， 被诊断患有双相情感障碍的青少年 治疗的相关性 结果与脑谷氨酸，γ-氨基丁酸（GABA）和胆碱， 将通过体内质子磁共振波谱（1H MRS）测量 试图确定治疗反应的生物学预测因素。 候选人假设会有显著的相关性 大脑中GABA的增加，如测量下的综合面积， 双丙戊酸钠的曲线和症状反应的减少， 通过Young/弗里斯塔德躁狂评定量表（MRS）和临床 全球影响力（CGI）评级量表。 该奖项的影响可能是 情绪稳定剂的安全性和有效性的评价， 青春期前和青少年躁狂症，以及我们的临床 知识和生物学相关的这种疾病在青少年。 候选人接受过临床药理学的初步培训， 脑成像 研究计划旨在使候选人能够 在临床儿科发展方面发展更大的专业知识 精神药理学试验和神经影像学应用于临床精神病学。 五年职业发展计划包括以下方面的教学指导： 药物代谢动力学和临床研究在加州大学洛杉矶分校神经精神 研究所和加州大学洛杉矶分校脑成像部 医学院。 拟议的培训将包括生物统计学、计算机、 科学，伦理学，神经解剖学，神经化学，神经生理学， 神经药理学、药代动力学、统计分析和改良的 大脑图谱研究金课程。 该计划提供了 有机会学习传统和先进的磁共振成像 (MRI)适用于候选人特定临床领域的技术 兴趣（即，情绪障碍）。 除了促进候选人的 向独立研究过渡，拟议的研究也将有助于 药物治疗和可能的神经生物学 青少年躁郁症的标志物

DESCRIPTION (Adapted from applicant's abstract): The proposed Mentored Scientist Development Award For New Minority Faculty outlines a program of career development and research in psychopharmacology and neuroimaging of juveniles with bipolar disorder. A focus of this program will be a clinical trial with a mood-stabilizer (divalproex sodium) in a group of children and adolescents diagnosed with bipolar illness. The correlation of treatment outcome with brain glutamate, y-aminobutyric acid (GABA) and choline as measured by in vivo proton magnetic resonance spectroscopy (1H MRS) will be attempted to identify biological predictor factors of treatment response. The candidate hypothesizes that there will be a significant correlation between an increase in cerebral GABA as measured by integrated areas under the curve and a decrease in symptom response to divalproex sodium as measured by the Young/Fristad Mania Rating Scale (MRS) and the Clinical Global Impressions (CGI) rating scale. Implications of this award may be the evaluation of the safety and efficacy of a mood stabilizer in prepubertal and adolescent mania, and the broadening of our clinical knowledge and biological correlates of this disorder in juveniles. The candidate has received preliminary training in clinical pharmacology and brain imaging. The research plan is designed to enable the candidate to develop greater expertise in the development of clinical pediatric psychopharmacology trials and neuroimaging applied to clinical psychiatry. The five-year career development plan includes didactic instruction in pharmacokinetics and clinical research at the UCLA Neuropsychiatric Institute, and brain imaging at The Division of Brain Mapping of the UCLA School of Medicine. The proposed training would include courses in biostatistics, computer science, ethics, neuroanatomy, neurochemistry, neurophysiology, neuropharmacology, pharmacokinetics, statistical analysis, and a modified fellowship curriculum in brain mapping. The program provides the opportunities to learn conventional and advanced magnetic resonance imaging (MRI) techniques applicable to the candidate's specific area of clinical interest (i.e., mood disorders). In addition to furthering the candidate's transition to independent research, the proposed study would also contribute to our knowledge of pharmacological treatment and possible neurobiological markers of juvenile bipolar disorder.