AGING, EXERCISE AND ENDOTHELIAL FUNCTION

描述 （摘自申请人摘要）申请人Christopher A.德索萨 哲学博士、是一名生理学家，目前拥有一个非终身教职的教师队伍， 在科罗拉多大学运动机能学系任职。 博士DeSouza已经证明了学术工作的一贯重点和记录 在体力活动、衰老和心血管疾病风险方面 因素 他的职业目标是发展一个独立的校外资助 一个研究实验室，其使命是：1）研究物理 活动，因为它涉及到人类健康，疾病和老龄化;和，2） 本科生、研究生和博士后的科学培训 伙计们 少数民族指导研究科学家发展奖 学院将提供研究和职业发展计划。 的 研究和职业发展计划包括两个主要要素：1） 获得大量新的研究技能; 2） 结构化的活动，包括研究道德的正式课程， 生物统计学;参加期刊俱乐部和系列研讨会;定期 指导互动;以及出席科学会议。 此外 申办者和资深研究者咨询委员会 以及在拟议研究的各个方面具有专业知识的教职员工 并制定了职业发展计划，以指导DeSouza博士。 研究计划。 该研究项目的总体目标是确定 是否内皮功能随着年龄的增长而下降， 以及定期有氧运动是否能恢复 中年人内皮功能的一些（如果不是全部的话）丧失， 久坐的老年人。 一般假设是内皮功能 在体力活动人群中， 有氧运动可增强中老年血管内皮功能 坐着的成年人 支持这一假设的结果将提供新的和 有益的生理和临床见解的倡导定期 有氧运动作为一种治疗策略的小学和中学 预防与年龄相关的内皮功能障碍。 环境 DeSouza博士的培训环境非常出色。 赞助商，道格拉斯R。Seals博士，是一个既定的调查员， 导师在综合心血管研究，并有一个资金充足， 实验室 他和接待部门将为DeSouza博士提供所有 成功完成培训所需的资源。 (End的 摘要）

DESCRIPTION (Adapted from applicant's abstract) The applicant, Christopher A. DeSouza, Ph.D., is a physiologist currently holding a non-tenure track faculty appointment in the Department of Kinesiology at the University of Colorado. Dr. DeSouza has demonstrated a consistent focus and record of scholarly work in the area of physical activity, aging, and cardiovascular disease risk factors. His career goal is to develop an independent extramurally-funded research laboratory which has as its mission: 1) the study of physical activity as it pertains to human health, disease, and aging; and, 2) the scientific training of undergraduate and graduate students, and postdoctoral fellows. The Mentored Research Scientist Development Award for Minority Faculty would provide the Research and Career Development Plan. The research and career development plan consists of 2 primary elements: 1) the acquisition of an impressive number of new research skills; and 2) structured activities including formal course-work in research ethics and biostatistics; participation in journal clubs and seminar series; regular mentoring interactions; and attendance at scientific meetings. In addition to the sponsor, and advisory committee of established senior investigators and faculty members with expertise in all aspects of the proposed research and career development plan has been formed to mentor Dr. DeSouza. Research Plan. The general aim of the research project is to determine whether endothelial function declines with age in physically active populations and whether a program of regular aerobic exercise can restore some, if not all, of the loss in endothelial function in middle-aged and older sedentary adults. The general hypothesis is that endothelial function does not decline with age in physically active populations and that regular aerobic exercise can enhance endothelial function in middle-aged and older sedentary adults. Results supporting this hypothesis would provide new and useful physiological and clinical insight into the advocacy of regular aerobic exercise as a therapeutic strategy for both primary and secondary prevention of age-related endothelial dysfunction. Environment. The environment for Dr. DeSouza's training is outstanding. The sponsor, Douglas R. Seals, Ph.D., is an established investigator and mentor in integrative cardiovascular research, and has a well-funded laboratory. He and the host department will provide Dr. DeSouza all of the necessary resources to successfully complete his training. (End of Abstract)