GENETIC MODELING OF PSYCHOPATHOLOGY

描述(改编自申请人的摘要)：这是一份申请 职业发展奖。此应用程序的目的是确保 申请者有足够的时间进行研究，这是持续发展所必需的 作为一名统计遗传学的独立研究员，她的职业生涯 精神病学的应用，以及提供额外的临床 训练。应聘者是统计学应用方面的专家 精神病学研究的方法。从1990年到1995年，她得到了一项 曾获NIMH职业发展奖。在这段时间里，她获得了 在人类和精神病学遗传学方面有广泛的背景，并发展了她的技能 在她自己的专业领域，她已经做出了几个基本的 对精神病学研究中的统计方法领域的贡献。 她最近被聘为伦敦政治经济学院的教员。 爱荷华大学的医学，它有一个杰出的研究项目 精神病学和对遗传学研究的坚定承诺。 精神疾病潜在遗传机制的发现可以 促进诊断和预防，帮助开发更多 有效的干预措施，并扩大对以下方面贡献的理解 从先天到后天都是精神病态。巨大的技术进步 近年来已经对复杂的基因进行了复杂的建模 精神障碍在原则上可行。然而，理论上可用的是 在实践中并不总是可行的。困难的根本来源 涉及适当的抽样程序(确定家庭)和 数据分析中抽样的适当数学处理。未解决 抽样问题可以使计划和执行一项遗传研究 复杂的障碍是极其困难的。拟议的研究将解决 使用两种分析方法进行复杂遗传分析的主要抽样问题 数学方法和模拟研究。候选人坚持认为 持续与临床医生在遗传研究方面建立合作关系 恐慌症、自闭症和强迫症。都是理论上的 工作将以这些数据的分析为指导和应用 学习。

DESCRIPTION (Adapted from applicant's abstract): This is a request for a Career Development Award. The purpose of this application is to ensure the applicant adequate time for research, necessary to the continued development of her career as an independent investigator in statistical genetics with psychiatric applications, as well as to provide additional clinical training. The candidate is an expert in the application of statistical methods in psychiatric research. From 1990-1995 she has been supported by a prior NIMH Career Development Award. During the time she has acquired a broad background in human and psychiatric genetics and developed her skills in her own area of expertise, and she has already made several fundamental contributions to the field of statistical methods in psychiatric research. She has recently been recruited to join the faculty of The College of Medicine at the University of Iowa which has an outstanding research program in psychiatry and a strong commitment to genetics research. The discovery of genetic mechanisms underlying psychiatric disorders can facilitate diagnosis and prevention, aid in the development of more effective interventions, and broaden understanding of the contributions of both nature and nurture to psychopathology. Enormous technologic advances in recent years have made sophisticated modeling of complex genetic disorders feasible in principle. However, what is available in theory is not always feasible in practice. A fundamental source of difficulty involves proper procedures for sampling (ascertainment of families) and proper mathematical treatment of sampling in data analysis. Unresolved sampling problems can make planning and executing a genetic study of a complex disorder extremely difficult. The proposed research will address major sampling issues for complex genetic analysis using both analytic mathematical approaches and simulation studies. The candidate maintains ongoing established collaborations with clinicians on genetic studies of panic disorder, autism, and obsessive-compulsive disorder. All theoretical work will be both guided by and applied to the analysis of data from these studies.