Discovering Optimal Weight Loss Interventions to Prevent Osteoarthritis in Obesity Through the Lens of Early Biomarkers: the TANGO Diet Trial

骨关节炎（OA）是最常见的关节炎类型，肥胖人群增加了OA的疾病负担。减肥是缓解症状的第一线管理，但尚不清楚减肥是否可以防止关节OA的变化。生物OA标记物可以在常规X光检查出现任何迹象之前很久就发现早期疾病变化。我的研究将着眼于通过极低能量饮食减肥对超重或肥胖患者早期OA生物标志物的影响。

Osteoarthritis (OA) is the most common type of arthritis, and an obese population increases the disease burden of OA. Weight-loss is the first line management for symptom relief but is unclear whether weight loss can prevent OA changes in the joint. Biological OA markers can pick up early disease changes long before any signs on routine X-ray. My research will look at the effect of weight loss by very low energy diet on early OA biomarker in patients with overweight or obesity.