BEHAVIORAL DYSREGULATION: LIABILITY TO DRUG ABUSE

这一竞争性续订K02提案扩展了 儿童调节障碍问卷(DI)于年前5年开始编制 这个项目。PI将准备一份计算机化的适应性测试版本 纸质和铅笔版本的DI。使用DI，这一前景 调查将针对确定监管失衡的程度 是青少年使用ATOD的易感表型，从长远来看，也是SUD的易感表型。 后一个目标将通过研究调控失调在 安非他明类兴奋剂使用严重程度从儿童到青少年的进展 (1)家庭和同伴社会化进程的背景，(2)加强 药物的作用；(3)性别差异。此外，中国的贡献 对ATOD使用责任代际传递的不规范将 将被澄清。 样本是通过NIDA资助的教育和药物中心招募的 虐待研究(雪松)，其中梅齐奇博士是共同派。1999年，雪松发起了 这项前瞻性研究的第11-15年。样本由两组组成：1) 生父的男女子女终身DSM-IR-R 诊断为SUD(n=321)和2)一组匹配的无 SUD或其他Axis I精神障碍(n=188)。在基线上，受试者是 10-12岁。他们在12-14岁、16岁、19岁、22岁和 此后每年使用全面的生物行为方案，直到30岁 包括分子遗传学、生化、内分泌学、 神经生理、心理、家庭互动和社会人口学 测量。然而，这个K02项目建议研究年龄的对象 10-12、12-14和16。

This competitive renewal K02 proposal extends the psychometric development of the childhood Dysregulation Inventory (DI) initiated in the first 5 years of this project. The PI will prepare a computerized adaptive test version of the paper and pencil version of the DI. Using the DI, this prospective investigation will be directed at determining the extent to which dysregulation is a liability phenotype to adolescent ATOD use, and in the long term, to SUD. This latter goal will be accomplished by studying the role of dysregulation in the progression of the severity of ATOD use from childhood to adolescence in the context of (1) family and peer socialization processes, (2) the reinforcing effects of drugs, and (3) gender differences. Furthermore, the contribution of dysregulation to the intergenerational transmission of ATOD use liability will be elucidated. The sample is recruited through the NIDA-funded Center for Education and Drug Abuse Research (CEDAR) where Dr. Mezzich is Co-PI. In 1999, CEDAR initiated years 11-15 of this prospective study. The sample consists of two groups: 1) male and female children of biological fathers with a lifetime DSM-IR-R diagnosis of SUD (n=321) and 2) a matched group of offspring of men who have no SUD or other Axis I psychiatric disorder (n=188). At baseline, the subjects are 10-12 years of age. They are re-evaluated at ages 12-14, 16, 19, 22 and annually thereafter until age 30 using a comprehensive biobehavioral protocol encompassing molecular genetic, biochemical, endocrinological, neurophysiological, psychological, family interaction, and sociodemographic measurements. However, this K02 project proposes to study the subjects at ages 10-12, 12-14, and 16.