CHRONIC HYPOXIA, UTERINE ARTERY VASOREGULATION & GROWTH

描述：（改编自申请人摘要）研究者 建议确定怀孕和慢性 缺氧影响子宫动脉血管调节和生长， 导致胎儿生长受限和可能的先兆子痫。的 核心工作假设是慢性缺氧损害 子宫动脉的血管调节和生长相关反应。的 假设将通过在三个具体的实验进行测试， 目标。(1)确定妊娠和慢性缺氧对 子宫动脉血管舒张/收缩反应的生理 刺激的流量，压力，和药理剂;（2）确定 妊娠和/或慢性缺氧对子宫动脉生长的影响;以及 (3)确定妊娠和/或慢性缺氧对 子宫动脉血管调节功能受损指标与 子宫动脉血流的增长，宫内生长受限， 和先兆子痫目标1和目标2将在孕妇和 未妊娠豚鼠在整个妊娠期间保持在1600 m和3962 m。 目标3侧重于居住在低海拔或高海拔地区的妇女， 多普勒流速仪和超声成像将用于测量 子宫动脉血流

DESCRIPTION: (Adapted from applicant's abstract) The investigator proposes to determine the mechanisms by which pregnancy and chronic hypoxia influence uterine artery vasoregulation and growth, and thus contribute to fetal growth restriction and possibly pre-eclampsia. The central working hypothesis is that chronic hypoxia impairs vasoregulatory and growth related responses of the uterine artery. The hypothesis will be tested by experiments performed in three specific aims. (1) Determine the effects of pregnancy and chronic hypoxia on uterine artery vasodilators/constrictor responses to the physiological stimuli of flow, pressure, and pharmacological agents; (2) Determine the effect of pregnancy and/or chronic hypoxia on uterine artery growth; and (3) Determine the effect of pregnancy and/or chronic hypoxia on the relationship of indices of impaired uterine artery vasoregulation and growth to uterine artery blood flow, intrauterine growth restriction, and pre-eclampsia. Aims #1 and #2 are to be conducted on pregnant and non-pregnant guinea pigs kept at 1600m and 3962m throughout pregnancy. Aim #3 focuses on women residing at either low or high altitude in whom Doppler flow velocimetry and ultrasound imaging will be used to measure uterine artery blood flow.