BIOFUNCTIONAL MATERIALS CONTAINING PROTEIN MIMETICS

血液单核细胞来源的巨噬细胞（一类吞噬白细胞）在指导炎症和异物对生物材料的反应中起着关键作用。然而，导致巨噬细胞粘附和激活材料的过程是复杂的，尚未完全了解。因此，我们对巨噬细胞与物质的相互作用和巨噬细胞的粘附和激活感兴趣。其次，我们希望在材料设计中利用这些知识，并对巨噬细胞活性蛋白和细胞膜上受体之间的相互作用有基本的了解。寡肽将根据已知的调节炎症的结构结构来设计。这些蛋白质模拟肽将被用于探索配体受体识别和细胞功能诱导所需的分子机制。就生物活性肽的生产而言。将开发和优化异功能聚合物材料，以提高巨噬细胞活性寡肽在体内和体外的物理化学性质和生物利用度。本研究计划提供了一种系统的方法来研究蛋白质-受体相互作用，并开发旨在调节内源性炎症细胞产生的选定细胞因子和生长因子释放的材料结构。这些生物活性因子的控制释放可能在炎症、生物相容性和组织愈合的基本过程中具有治疗价值。

Blood monocyte-derived macrophages (a class of phagocytic leukocytes) play a critical role in directing inflammation and foreign body reaction to biomaterials. However, the processes leading to macrophage adhesion and activation on materials are complex and not yet fully understood. Hence, our interest in macrophage interaction with material macrophage adhesion and activation. Second, we would like to exploit that knowledge in the design of materials and fundamental understanding of the interplay between macrophage-active proteins and receptors on the cell membranes must be obtained. Oligopeptides will be designed based on the known structural structure of modulating inflammation. These protein mimetic peptides will be utilized to probe the molecular mechanisms required for ligand-receptor recognition and the induction of cellular functions. In term, the bioactive peptides production. Heterofunctionalized polymeric materials will be developed and optimized to enhanced the physicochemical properties and bioavailability of macrophage-active oligopeptides in vitro and in vivo. This research plan offers a systematic method in the study of protein-receptor interaction and the development of material constructs designed to modulate the release of selected cytokines and growth factors produced by endogenous inflammatory cells. The controlled release of these bioactive factors may have therapeutic values in the fundamental processes of inflammation, biocompatibility, and tissue healing.