RISK FACTORS FOR AGE-RELATED EYE DISEASES

描述：（候选人的摘要）这是一个修改后的应用程序， K 08（原K11）奖，用于培训Debra Schaumberg博士， 流行病学 该计划包括流行病学研究生课程 哈佛大学公共卫生学院（HSPH）的生物统计学， 预防医学部的研讨会和研究会议 在布里格姆妇女医院和HSPH，并根据研究 继续指导博士查尔斯Hennekens，哈佛教授 医学和流行病学。 职业发展的总体目标 计划是：1）建立一个强大的流行病学学术基础， 包括完成哈佛科学博士学位（2）整合 教学式学习与实践研究经验，以取得进展 成为一名独立研究员 以前的研究已经提出了 白内障、年龄相关性黄斑变性（AMD）和 心血管疾病（CVD）可能有共同的风险因素。 拟议 研究将调查心血管疾病危险因素的共同性， 白内障和AMD。 该项目的健康相关性在于， 白内障和AMD是失明和视力损害的主要原因 国际吧 研究计划的具体目标是：1）确定 白内障的潜在独立预测因子包括高血压， 抗高血压药物和体重变异性;以及2） 研究AMD是否与CVD有共同的危险因素， 特别是高血压，抗高血压药物，体重指数， 体力活动和饮食因素，包括饱和脂肪，欧米茄-3 脂肪酸和类胡萝卜素。方法：本研究将从 数据收集是国家眼科研究所资助的 维生素补充剂与眼部疾病的随机试验 正在进行的医生健康研究。 这将提供一个独特的 Schaumberg博士进行前瞻性观察的机会 使用基线和更新的风险因素信息进行的研究， 白内障和AMD事件的自我报告记录了更多 对22,071名男性进行了超过12年的随访。 的长期目标 这项研究旨在有助于更好地了解病因 以及这些常见致盲疾病的风险因素， 为他们的预防。

DESCRIPTION: (Candidate's Abstract) This is a revised application for a K08 (formerly K11) Award to train Dr. Debra Schaumberg in epidemiology. The program consists of graduate courses in epidemiology and biostatistics at the Harvard School of Public Health (HSPH), seminars and research meetings at the Division of Preventive Medicine at the Brigham and Women's Hospital and HSPH, and research under the continued mentorship of Dr. Charles Hennekens, Harvard Professor of Medicine and Epidemiology. The overall goals of the career development plan are: 1) to develop a strong academic foundation in epidemiology, including completion of the Harvard Sc.D. degree, and 2) to integrate didactic learning with hands-on research experience in order to progress into an independent researcher. Previous studies have raised the possibility that cataract, age-related macular degeneration (AMD), and cardiovascular disease (CVD) may share common risk factors. The proposed studies will investigate the commonality of CVD risk factors with cataract and AMD. The health-relatedness of the project is that cataract and AMD are leading causes of blindness and visual impairment worldwide. The specific aims of the research plan are: 1) to identify potential independent predictors of cataract including hypertension, antihypertensive medications, and body weight variability; and 2) to investigate whether AMD shares common risk factors with CVD, in particular hypertension, antihypertensive medications, body mass index, physical activity, and dietary factors including saturated fats, omega-3 fatty acids, and carotenoids. Methods: The research will emanate from data being collected as part of the National Eye Institute-funded Randomized Trials of Vitamin Supplements and Eye Disease substudy of the ongoing Physicians' Health Study. This will provide a unique opportunity for Dr. Schaumberg to perform prospective observational studies using baseline and updated risk factor information and confirmed self-reports of incident cases of cataract and AMD documented over more than 12 years of follow-up of 22,071 men. The long-term objective of this research is to contribute to a better understanding of the etiology and risk factors for these common blinding diseases so that progress can be made toward their prevention.