CHIRAL CONJUGATED POLYMER BASED SENSORS

描述：(首席调查员) 一种新型光电传感器的研究 手性有机化合物和药物的对映体选择性识别 分子已被提出。这些传感器是通过使用 光学活性双萘基主链手性共轭 材料。不同的分子受体，如冠醚， 多铵大环和二硼酸的功能将 加入到手性共轭聚合物中。这些材料将 用于分析分子，如手性胺、氨基酸、手性 磷酸盐、手性羧酸盐、手性醇和糖。由于 这些新型共轭聚合物的手性，他们将能够 鉴别底物的对映体。合成与研究 此外，还提出了联萘类手性共轭树枝状大分子的合成方法。在……里面 主链手性稳定的聚合物研究综述 构型，我们还建议制备一种非手性交叉共轭 在手性存在的情况下可以表现出主链手性的聚合物 客人们。 这种诱导的主链手性将被用来区分 手性分子的对映体。通过对这些共轭分子的研究 手性主体聚合物，有望开发出一类高度 具有快速响应的灵敏和对映体选择性传感器。这个 这些传感器与衬底的相互作用将通过以下方式进行研究 分析它们的UV-Vis吸收、荧光、磷光、CD 效应和电化学。这项研究将带来全新的 科学和重要的实际应用。

DESCRIPTION: (Principal Investigator's) The study of novel electrical and optical sensors for the enantioselective recognition of chiral organic compounds and drug molecules has been proposed. These sensors are constructed by using optically active binaphthyl-based main chain chiral conjugated materials. Different molecular receptors such as crown ethers, polyammonium macrocycles and diboronic acid functions will be incorporated into the chiral conjugated polymers. These materials will be used to analyze molecules such as chiral amines, amino acids, chiral phosphates, chiral carboxylates, chiral alcohols and sugars. Due to the chirality of these novel conjugated polymers, they will be able to differentiate the enantiomers of the substrates. The synthesis and study of binaphthyl-based chiral conjugated dendrimers is also proposed. In addition to the research on the polymers with stable main chain chiral configuration, we also propose to prepare an achiral cross-conjugated polymer that can exhibit main chain chirality in the presence of chiral guests. This induced main chain chirality will be used to discriminate the enantiomers of chiral molecules. Through the study of these conjugated chiral host polymers, it is expected to develop a class of highly sensitive and enantioselective sensors with rapid responses. The interaction of these sensors with substrates will be investigated by analyzing their UV-vis absorptions, fluorescences, phosphorescences, CD effects and electrochemistry. This study will lead to fundamentally new sciences and important practical applications.