CELLULAR AND MOLECULAR STUDIES OF AUTOIMMUNE DISEASES

该项目由三个研究项目和两个核心单元组成。这三个相互联系和合作的项目的总体目标是：a)更好地理解导致患有全身自身免疫性疾病的个体或动物产生自身抗体或自身反应性T细胞的分子和免疫生物学机制。b)探讨细胞介导的免疫机制在这些疾病中的作用。这项提议汇集了一组来自西奈山医学院的成熟的研究人员，他们一直积极参与自身免疫的调查。每个项目都采用独特的实验方法来解决与疾病相关的问题。该项目的优势在于使用互补的方法和不同的方法，在过去十年中，参与该项目的实验室之间进行了富有成效的合作，以解决相关的和新颖的问题。该项目将汇集来自分子生物学、生物化学、医学和免疫学等不同学科的具有深厚病理生理学背景和知识的研究人员。这种桥接将创建一个多学科的方法来解决与实验性人类系统性自身免疫性疾病的发病机制相关的基本问题。

The program project is composed of three research projects and two core units. The overall goal of these three interlocking and cooperative projects are: a) to develop a better understanding of molecular and immunobiological mehcanisms leading to the production of autoantibodies or autoreactive T cells in individuals or animals with systemic autoimmune diseases. b) To investigate the role of cell mediated immune mechanisms in these diseases. This proposal brings together a group of established investigators from Mount Sinai School of Medicine who have been actively involved in the investigation of autoimmunity. Each project utilizes a unique experimental approach to address disease related questions. The program s strength lies in the use of complementary approaches and different methodologies, which have resulted in productive collaborations between the laboratories involved in this program project during the past ten years to address pertinent and novel questions. This program project will collectively bridge investigators with strong backgrounds and knowledge in pathophysiology from various disciplines: molecular biology, biochemistry, medicine and immunology. This bridging will create a multi-disciplinary approach to basic questions related to the pathogenesis of experimental human systemic autoimmune disease.