CORE--TRANSPORTER DATABASE AND STRUCTURE WEBSITE

许多实验室正在对5-羟色胺、去甲肾上腺素和多巴胺转运蛋白（分别为SERT、NET和DAT）以及NaCl偶联转运蛋白家族中的相关转运蛋白进行突变。这些转运蛋白突变体的性质发表在许多科学文章中，广泛分布在文献中。这个核心将创建一个数据库，包含该转运蛋白家族任何成员中所有已发表的突变。突变将根据位置、家族成员和对转运蛋白功能的影响进行组织。调查结果将在万维网上公布，以便任何人都能方便地获得信息。我们期望这将促进这一领域信息的快速共享，并将使许多药物滥用研究人员受益。随着结构建模工作通过该计划的实验结果变得更加精细，我们还打算展示转运蛋白家族的当前结构模型。该模型的三维表示将可供网站访问者使用VRML（虚拟现实标记语言）进行倾斜和旋转。

Many laboratories are making mutations in the serotonin, norepinephrine, and dopamine transporters (SERT, NET and DAT, respectively) and in related transporters in the NaCl-coupled transporter family. The properties of these transporter mutants are published in many scientific articles scattered widely through the literature. This core will create a database of all published mutations in any member of this transporter family. The mutations will be organized according to position, family member and the effect on transporter function. The results will be presented in a World Wide Web site so that anyone can access the information easily. We expect that this will facilitate the rapid sharing of information in this field, and will benefit many drug abuse researchers. As the structural modeling efforts become more refined by the experimental results from this program, we intend also to display the current structural model for the transporter family. A three dimensional representation of this model will be available for visitors to the website to tilt and rotate using VRML (Virtual Reality Markup Language).