TRAINING IN ALCOHOL AND NEURODEGENERATIVE DISEASE

描述：本续篇提案概述了一个全面的、跨学科的神经科学项目，主要涉及酒精性神经退行性疾病的研究、教育和培训。这项培训计划将继续在酒精研究中心和佛罗里达大学健康科学中心内的佛罗里达大学脑研究所的主持下进行。我们的培训导师包括16名教师，横跨健康中心三个学院的六个系。申请经费为3名博士预科生和3名博士后研修生提供津贴。我们的项目利用佛罗里达大学跨学科神经科学研究的历史和实力，为培养高素质的医学研究专业人员提供必要的背景、经验和环境。学员可以参与的研究领域包括：乙醇对发育中的动物（Heaton, Walker）和人类（Behnke, Eyler）的有害作用；神经营养因子在乙醇神经毒性中的作用（Walker, Heaton, King, MacLennan）；兴奋性毒性和兴奋性氨基酸在酒精变性中的作用（Anderson, Freund, Vickroy）；乙醇在信号转导和突触可塑性中断中的作用（King, Meyer, Pen's, Papke）；多巴胺能和gaba能受体相互作用在介导乙醇和可卡因共同滥用中的作用（MacLennan, Pen’s），以及乙醇与其他常见滥用药物相互作用的机制（Meyer, Papke, Vickroy）；离子电流和通道在乙醇神经毒性中的作用（Posner, Walker, King）；乙醇对胶质细胞形成和细胞因子表达的影响（Streit）。我们的培训计划还包括一个教育部分，包括医学神经科学，分子神经生物学，拨款写作和科学伦理，以及酒精和酒精中毒的神经生物学和神经药理学的有限课程。该培训项目将与我们现有的神经生物学、衰老神经生物学和佛罗里达大学脑研究所等强大的跨学科培训中心相结合，在神经退行性疾病方面提供全面和综合的神经科学培训。

DESCRIPTION: This continuation proposal outlines a comprehensive, interdisciplinary program in the neurosciences leading to research, education and training in alcoholic neurodegenerative disease. This training program will continue to be performed under the auspices of the Center for Alcohol Research and the University of Florida Brain Institute within the Health Science Center of the University of Florida. Our training preceptors includes 16 faculty members spanning six Departments in three Colleges within the Health Center. Funding is requested to provide stipends for three predoctoral and three postdoctoral trainees. Our program takes advantage of the history and strength in interdisciplinary neuroscience research at the University of Florida to provide the necessary context, experience and environment conducive to the training of highly-qualified medical research professionals. Research areas in which trainees can participate includes studies of: The deleterious actions of ethanol in developing animals (Heaton, Walker) and humans (Behnke, Eyler); the role of neurotrophic factors in ethanol neurotoxicity (Walker, Heaton, King, MacLennan); the role of excitotoxicity and excitatory amino acids in alcohol degeneration (Anderson, Freund, Vickroy); the role of ethanol in disruption of signal transduction and synaptic plasticity (King, Meyer, Pen's, Papke); the role of dopaminergic and GABAergic receptor interactions in mediating the actions of ethanol and cocaine co-abuse (MacLennan, Pen's) as well as mechanisms for interaction of ethanol with other commonly abused drugs (Meyer, Papke, Vickroy); the role of ion currents and channels in ethanol neurotoxicity (Posner, Walker, King); and ethanol effects of gliogenesis and cytokine expression (Streit). Our training plan also includes an educational component encompassing limited coursework in medical neurosciences, molecular neurobiology, grant writing and scientific ethics, and the neurobiology and neuropharmacology of alcohol and alcoholism. This training program will be integrated with our strong, existing interdisciplinary training centers in the neurobiological sciences, the neurobiology of aging and the University of Florida Brain Institute to provide comprehensive and integrated neuroscience training in neurodegenerative disease.