CORE--MOLECULAR ANALYSIS

以皮肤为中心的基础科学研究， 和机械需要使用多种调查工具， 技术. 对于任何一个实验室来说， 开发所有必要的工具，以充分解决复杂的问题 涉及皮肤生物学和皮肤相关疾病。 所需设备为 对于任何一个调查员来说， 获取。 此外，精密设备的最佳操作 或执行困难的测定，最好由专门的经验丰富的 人员的 分子分析核心将提供各种各样的 为ESDRC研究者提供服务、专业知识和试剂， 方便他们的学习。 细胞粘附组件将提供 专门基质蛋白，将有助于设计和执行细胞粘附 实验使用静态和流动系统，并将提供 探索流体流动影响的研究方法 对细胞膜信号传导和生理和 病理生理反应 微量化学成分将提供 专门的肽和寡核苷酸、蛋白质测序和HPLC。 流式细胞术/细胞分选组件将提供多参数 流式细胞术分析、细胞分选和细胞周期分析。 这 核心将为ESDRC调查人员提供宝贵的资源， 将明显促进对基本皮肤生物学的研究， 跨多学科研究领域的合作研究。

Basic science oriented skin centered research that is both comprehensive and mechanistic requires the use of multiple investigative tools and techniques. It is extremely difficult for any single laboratory to develop all the necessary tools to fully address complicated issues concerning skin biology and skin related disease. Equipment required is likely to be prohibitively expensive for any single investigator to acquire. Additionally, the optimal operation of sophisticated equipment or execution of difficult assays is best done by dedicated experienced personnel. The Molecular Analysis Core will provide a wide variety of services, expertise, and reagents to ESDRC investigators which will facilitate their studies. The Cell Adhesion Component will provide specialize matrix proteins, will help design and execute cell adhesion experiments using both static and flow systems, and will provide for investigative methodologies which explore the effects of fluid flow dynamics upon cell membrane signalling and physiologic and pathophysiologic responses. The Microchemical Component will provide specialized peptides and oligonucleotides, protein sequencing, and HPLC. The Flow cytometric/Cell Sorting Component will provide multiparameter flow cytometric analysis, cell sorting, and cell cycle analysis. This core will provide ESDRC investigators with an invaluable resources which will clearly facilitate investigations into basic skin biology and foster collaborative investigations across multidisciplinary fields of research.