PROCEDURES TO ASSESS THE HAZARDS OF A SUPERFUND SITE

该超级基金计划的主要重点仍然是发展和 可用于风险评估的体内和体外生物测定的验证 评估含油废物和木材防腐废物。一个目标是 开发和验证各种不同的化学类别的具体 可用于复杂有毒物质风险评估的生物测定 混合物。为了实现这一目标，该项目采用了两种模式 化合物和重构混合物，以确定 个别同源物和添加剂或非添加剂的相互作用， 混合物中观察到。在一些研究中， 从特定危险废物中获得的混合物的生物化学效应 地点也已确定。报告了在确定 某些化合物的相对效价或毒性当量因子（TEF） 最具毒性的化合物， 监管机构目前正在使用这种方法进行风险评估 国际吧

The major focus of this Superfund Program remains the development and validation of in vivo and in vitro bioassays which can be used for risk assessment of oily and wood-preserving wastes. One goal has been to develop and validate a variety of diverse chemical class-specific bioassays that can be utilized for risk assessment of complex toxic mixtures. To achieve this aim, the project has utilized both model compounds and reconstituted mixtures to determine relative potencies of individual congeners and the additive or non-additive interactions which are observed for mixtures. In some studies, the toxic and/or biochemical effects of mixtures obtained from specific hazardous waste sites have also been determined. Progress is reported in determining relative potencies or toxic equivalency factors (TEFs) for some of the most toxic individual compounds that have been identified, and this approach is now being utilized for risk assessment by regulatory agencies worldwide.