INFLUENCE OF OBESITY ON ENDOGENOUS SUBSTRATE UTILIZATION DURING EXERCISE

这项研究的主要目标将是检验这样一种假设，即肥胖和瘦的人在低强度运动中的脂质氧化减少。这项研究将测量运动中的脂肪和碳水化合物的利用，并验证运动中的脂肪氧化在肥胖中受损的假设。这项研究将招募精瘦和肥胖的久坐男性。肥胖者的骨骼肌代谢调节存在静息状态的缺陷，尽管肥胖症患者在运动过程中利用底物的信息很少。身体成分将由DEXA测定。60分钟运动中的底物利用率将使用间接量热法和游离脂肪酸(FFA)和葡萄糖的稳定同位素示踪剂来确定。

The primary objective of this study will be to examine the hypothesis that lipid oxidation during low intensity exercise is reduced in obese versus lean individuals. This study will measure lipid and carbohydrate utilization during exercise and test the hypothesis that lipid oxidation during exercise is impaired in obesity. Lean and obese sedentary males will be recruited for this study. Defects in the regulation of skeletal muscle metabolism are present at rest in obese individuals, although information regarding substrate utilization during exercise in obesity is scarce. Body composition will be determined by DEXA. Substrate utilization during 60 minutes of exercise will be determined using indirect calorimetry and stable isotope tracers of free fatty acids (FFA) and glucose.