REACH--REACHING FOR EXCELLENCE IN ADOLESCENT HEALTH CARE

REACH项目是一项关于通过性行为或针头感染的青少年中艾滋病毒感染的研究。自从REACH项目在费城儿童医院启动以来，共有47名受试者被招募；39名受试者仍在学习中。REACH项目研究青少年中艾滋病毒感染的谱系，深入研究艾滋病毒感染对这一人群的免疫学、病毒学和行为影响。这项研究还研究了该人群中艾滋病毒感染的其他方面，包括HPV感染、宫颈异位以及其他性传播疾病对疾病的影响。这项研究延长了两年，以便有更多的时间对这一队列进行观察。该项目目前正在提供关于感染的免疫反应、伴随的HPV感染的影响、CD4+T淋巴细胞与血浆病毒载量的相关性以及该人群中存在的心理社会应对机制的数据，其中一些数据已提交发表。费城儿童医院的临床研究中心在帮助处理作为这项研究的一部分收集的许多标本方面发挥了至关重要的作用。随着这项研究的延长，临床研究中心的继续使用将对完成这项研究至关重要。

The REACH Project is a study of HIV infection in adolescents infected through either sexual behavior or needle use. A total of 47 subjects have been recruited into the REACH Project since it opened here at The Children's Hospital of Philadelphia; 39 subjects remain on study. The REACH Project studies the spectrum of HIV infection in adolescents, with intensive studies of the immunological, virological, and behavioral impact of HIV infection in this population. The study also studies other aspects of HIV infection in this population including HPV infection, cervical ectopy, and the disease impact of other sexually transmitted diseases. The study has been extended for two years in order to have greater time of observation for this cohort. Data are now becoming available from the Project, some of which has been submitted for publication, concerning the immunologic response to infection, the impact of concomitant HPV infection, the correlation of CD4+T lymphocytes and the plasma viral load, and the psychosocial coping mechanisms present in this population. The Clinical Research Center at The Children's Hospital of Philadelphia has been vital in helping to process the many specimens collected as part of this study. As this study has been extended, the continued use of the Clinical Research Center will be vital for completion of the study.