NMR STRUCTURAL STUDIES OF DNA BINDING DOMAIN OF CBF(
NMR STRUCTURAL STUDIES OF DNA BINDING DOMAIN OF CBF(
批准号:
6120909
负责人:
JOHN Hackett BUSHWELLER
金额:
$1.84万
依托单位国家:
美国
项目类别:
财政年份:
1999
资助国家:
美国
项目状态:
已结题
起止时间:
1999-03-01 至 2000-02-29
中文摘要
反胶束具有广泛的应用。 它们可以
用作微反应器,以进行生物技术感兴趣的反应,
并具有许多与以下有关的药物应用:
以便于药物的输送。 然而,为了充分发挥潜力,
要达到这些应用程序,必须了解
环境,溶质的经验时,放置在一个反向
胶束 为了表征这种内部胶束环境,
我们使用31 P NMR来监测存在的水的表观pH
在反胶束内部作为水/表面活性剂的函数
比例和油/表面活性剂比例。 这些信息,如果与
粘度研究,使我们能够描绘内部胶束
环境被改造了。 我们现在建议进一步描述
反胶束及其内部环境,通过测量
系统中所有物质的自扩散系数
通过使用傅里叶变换脉冲场梯度自旋回波
实验
英文摘要
Reverse micelles have a wide variety of applications. They can be
used as microreactors to carry reactions of interest to the biotech
industry and have numerous pharmaceutical applications relating to
facilitating the delivery of drugs. However, for the full potential
of these applications to be reached one must understand the
environment that the solute experiences when placed inside a reverse
micelle. In order to characterize this internal micelle environment,
we are using 31P NMR to monitor the apparent pH of the water present
inside the reverse micelles as a function of the water/surfactant
ratios and oil/surfactant ratios. This information, when coupled with
viscosity studies, allow us to delineate how the internal micelle
environment is modified. We now propose to further characterize the
reverse micelle, and its internal environment, by measuring the
self-diffusion coefficients of all species present in the system
through the use of Fourier Transform Pulsed Field Gradient Spin-Echo
experiments.
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AF9(MLLT3) Function in Leukemia and Normal Hematopoiesis
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批准号:10378336
-
项目类别:
-
资助金额:$6.78万
-
财政年份:2019
-
负责人:JOHN Hackett BUSHWELLER
-
依托单位:
AF9(MLLT3) Function in Leukemia and Normal Hematopoiesis
-
批准号:10434785
-
项目类别:
-
资助金额:$58.98万
-
财政年份:2019
-
负责人:JOHN Hackett BUSHWELLER
-
依托单位:
Small Molecule Inhibitors of a Reader of DNA Methylation
-
批准号:9808362
-
项目类别:
-
资助金额:$20.19万
-
财政年份:2019
-
负责人:JOHN Hackett BUSHWELLER
-
依托单位:
AF9(MLLT3) Function in Leukemia and Normal Hematopoiesis
-
批准号:10667450
-
项目类别:
-
资助金额:$58.98万
-
财政年份:2019
-
负责人:JOHN Hackett BUSHWELLER
-
依托单位:
AF9(MLLT3) Function in Leukemia and Normal Hematopoiesis
-
批准号:10524126
-
项目类别:
-
资助金额:$6.58万
-
财政年份:2019
-
负责人:JOHN Hackett BUSHWELLER
-
依托单位:
AF9(MLLT3) Function in Leukemia and Normal Hematopoiesis
-
批准号:10198868
-
项目类别:
-
资助金额:$60.18万
-
财政年份:2019
-
负责人:JOHN Hackett BUSHWELLER
-
依托单位:
AF9(MLLT3) Function in Leukemia and Normal Hematopoiesis
-
批准号:10738333
-
项目类别:
-
资助金额:$6.58万
-
财政年份:2019
-
负责人:JOHN Hackett BUSHWELLER
-
依托单位:
Targeted Small Molecule Inhibitors for Inv(16) Leukemia
-
批准号:10307548
-
项目类别:
-
资助金额:$66.72万
-
财政年份:2018
-
负责人:JOHN Hackett BUSHWELLER
-
依托单位:
Targeted Small Molecule Inhibitors for Inv(16) Leukemia
-
批准号:10520054
-
项目类别:
-
资助金额:$66.69万
-
财政年份:2018
-
负责人:JOHN Hackett BUSHWELLER
-
依托单位:
Targeted Small Molecule Inhibitors for Inv(16) Leukemia
-
批准号:10056213
-
项目类别:
-
资助金额:$67.89万
-
财政年份:2018
-
负责人:JOHN Hackett BUSHWELLER
-
依托单位:
Structure/Function of AF9 and MLL-AF9
-
批准号:8974717
-
项目类别:
-
资助金额:$0.83万
-
财政年份:2014
-
负责人:JOHN Hackett BUSHWELLER
-
依托单位:
Structure/Function of AF9 and MLL-AF9
-
批准号:8311653
-
项目类别:
-
资助金额:$46.68万
-
财政年份:2011
-
负责人:JOHN Hackett BUSHWELLER
-
依托单位:
Structure/Function of AF9 and MLL-AF9
-
批准号:8504799
-
项目类别:
-
资助金额:$43.88万
-
财政年份:2011
-
负责人:JOHN Hackett BUSHWELLER
-
依托单位:
Structure/Function of AF9 and MLL-AF9
-
批准号:8193766
-
项目类别:
-
资助金额:$49.71万
-
财政年份:2011
-
负责人:JOHN Hackett BUSHWELLER
-
依托单位:
Structure/Function of AF9 and MLL-AF9
-
批准号:8677790
-
项目类别:
-
资助金额:$45.28万
-
财政年份:2011
-
负责人:JOHN Hackett BUSHWELLER
-
依托单位:
Development of Inhibitors of the Leukemia Fusion Protein CBFbeta-SMMHC
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批准号:8071203
-
项目类别:
-
资助金额:$64.24万
-
财政年份:2010
-
负责人:JOHN Hackett BUSHWELLER
-
依托单位:
Development of Inhibitors of the Leukemia Fusion Protein CBFbeta-SMMHC
-
批准号:8457974
-
项目类别:
-
资助金额:$59.31万
-
财政年份:2010
-
负责人:JOHN Hackett BUSHWELLER
-
依托单位:
Development of Inhibitors of the Leukemia Fusion Protein CBFbeta-SMMHC
-
批准号:7892198
-
项目类别:
-
资助金额:$68.69万
-
财政年份:2010
-
负责人:JOHN Hackett BUSHWELLER
-
依托单位:
Solution NMR Structure and Function of the Integral Membrane Protein DsbB
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批准号:7811029
-
项目类别:
-
资助金额:$17.6万
-
财政年份:2010
-
负责人:JOHN Hackett BUSHWELLER
-
依托单位:
Development of Inhibitors of the Leukemia Fusion Protein CBFbeta-SMMHC
-
批准号:8242873
-
项目类别:
-
资助金额:$63.09万
-
财政年份:2010
-
负责人:JOHN Hackett BUSHWELLER
-
依托单位:
海外基金