肺炎链球菌荚膜多糖抗体库-猫眼课题宝

肺炎链球菌荚膜多糖抗体库

批准号：

6119864

负责人：

ALEXANDER LUCAS

金额：

$2.58万

依托单位：

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

依托单位国家：

美国

项目类别：

财政年份：

资助国家：

美国

项目状态：

未结题

起止时间：

至

来源：

https://reporter.nih.gov/project-details/6119864

关键词：

Streptococcus pneumoniae antibacterial antibody antibody formation bacterial polysaccharides clinical research gene expression human subject immunoglobulin genes

中文摘要

翻译

肺炎链球菌是一种包囊细菌病原体，严重的侵袭性疾病。大量证据表明，针对荚膜多糖的抗体介导预防肺炎球菌感染。然而，事实上，已知这些重要抗体的克隆和分子多样性特殊性我们的实验目的是评估克隆性，成人抗体的可变区使用和功能特性对肺炎球菌多糖血清型6B、14和23F具有特异性。

英文摘要

Streptococcus pneumoniae is an encapsulated bacterial pathogen that causes serious invasive diseases. Considerable evidence indicates that antibodies directed against the capsular polysaccharides mediate protection against pneumococcal infection. However, little is actually known about the clonal and molecular diversity of these important antibody specificities. Our experimental aims are to evaluate the clonality, variable region usage and functional properties of adult antibodies specific for the pneumococcal polysaccharide serotypes 6B, 14 and 23F.

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