EFFECT OF CORRECTION OF SLEEP DISORDERED BREATHING ON DAYTIME HYPERTENSION

本研究将探讨清醒时血压与睡眠引起的呼吸暂停/低通气和打鼾相关的高上气道阻力的关系。 我们将在轻度和中度高血压患者中通过鼻持续气道正压通气（CPAP）治疗消除睡眠呼吸障碍（SDB）和打鼾，并确定对48小时动态血压测量和夜间儿茶酚胺释放的影响。我们假设，通过2周的鼻CPAP消除夜间呼吸将导致伴有SDB和打鼾的轻度/中度高血压受试者的血压降低，但不会影响没有SDB和打鼾的受试者的动脉压。 我们预测，在CPAP治疗期间降低血压的受试者中，夜间儿茶酚胺释放增加与日间血压控制相关。该研究的主要目的是应用鼻CPAP，这是一种可以快速逆转SDB和打鼾的干预措施，并在干预之前，期间和之后测量血压和尿儿茶酚胺释放。

This study will investigate the relationship-of waking blood pressure to sleep-induced apnea/hypopnea and high upper airway resistance associated with snoring. We will experimentally eliminate sleep disordered breathing (SDB) and snoring with nasal continuous positive airway pressure (CPAP) treatment in mild and moderate hypertensives and determine the effect on 48 hour ambulatory blood pressure measurements and nocturnal catecholamine release. We hypothesize that the elimination of nocturnal respiratory with 2 weeks of nasal CPAP will result in a reduction in blood pressure in mild/moderate hypertensive subjects with SDB and snoring but will not affect arterial pressure in those subjects without SDB and snoring. We predict that increased nocturnal catecholamine release will be correlated with daytime blood pressure control in subjects who lower their blood pressure during CPAP therapy. The main objective of the study is the application of nasal CPAP, an intervention that can rapidly reverse SDB and snoring, and the measurement of blood pressures and urinary catecholamine release before, during and after the intervention.