SNI-2011 TO TREAT PATIENTS WITH SJOGREN'S SYNDROME

干燥综合征是一种免疫性疾病，其特征在于眼干和口干，其包括腺体组织分泌减少或缺乏。 SNI-2011是乙酰胆碱的奎宁环衍生物，是一种毒蕈碱激动剂，可改善腺体分泌唾液和流泪的能力。 本研究将比较两种剂量的SNI-2011（15 mg和30 mg tid）与安慰剂对患者干燥（口、眼和总体）的主观总体评价的疗效。

Sjogren's syndrome is an immunological disorder characterized by dry eyes and dry mouth, which includes diminished or absent secretion of glandular tissue. SNI-2011, a quinuclidine derivative of acetylcholine, is a muscarinic agonist associated with improved glandular ability to increase salivation and lacrima-tion. This study will compare the efficacy of two doses of SNI-2011 (15 mg and 30 mg tid) with placebo on the patients' subjective global evaluation of dryness (mouth, eyes, and overall).