CORE--CLINICAL TRIAL PROTOCOL REVIEW AND MONITORING SYSTEM

方案审查制度包括1）癌症中心征集 研究人员将审查机构方案以获取 癌症中心的共享资源，2）会议审查 提交的机构方案，以及3）方案监测系统 确保及时执行和审查正在进行的方案。 这一核心设施的主要目的是提供一个有效的， 经济的方法，通过这种方法可以生产转基因小鼠， 圣安东尼奥癌症研究所。转基因小鼠的建立 生产能力涉及大量投资， 设备和人员培训，因此，通常 对于只需要一个小的实验室来说， 转基因小鼠的数量。此外，只有有限的选择转基因 圣安东尼奥癌症研究所已经获得了小鼠生产 成员在过去，涉及要么有老鼠生产商业化 或与少数几个 UTHSCSA或CTRC内目前生产转基因的实验室 小鼠因此，这一核心的主要目标是提供 安东尼奥癌症研究所成员的一种方法，通过这种方法，转基因小鼠可以 及时生产，成本反映实际成本 生产老鼠。其他相关服务包括 无病原体小鼠品系的再衍生和胚胎冷冻保存。

The protocol review system includes 1) solicitation of cancer center investigators for institutional protocols to be reviewed for access to the shared resources of the cancer center, 2) meetings to review submitted institutional protocols, and 3) a protocol monitoring system to assure timely conduct and review of ongoing protocols. The primary purpose of this core facility is to provide an efficient and economical means by which transgenic mice can be produced for members of the San Antonio Cancer Institute. The establishment of transgenic mouse production capabilities involves a substantial investment both in terms of equipment and in training of personnel and is, therefore, usually prohibitively expensive to individual laboratories requiring only a small number of transgenic mice. Further, only limited options for transgenic mouse production have been available to San Antonio Cancer Institute members in the past, involving either having mice produced commercially or establishing a collaboration with one of the small number of laboratories within the UTHSCSA or CTRC that currently produce transgenic mice. The primary objective of this core is therefore to provide San Antonio Cancer Institute members a means by which transgenic mice can be produced in a timely fashion and at a cost which reflects the actual cost of producing the mice. Additional, related services will include rederivation of pathogen-free mouse lines and embryo cryopreservation.