CORE--PHARMACOLOGY

ADRC临床药理学亚核。临床神经药理学 洛杉矶阿尔茨海默病研究中心联盟的次核心 洛杉矶和奥兰治县(ADRC)维护基础设施，以 支持、加强和促进临床药理学研究 亚洲发展研究中心。核心提高了临床研究的质量和 假设检验；增加进行的临床研究的种类； 并增加和加快患者获得ADRC研究的机会。这个 核心资源由个人持续利用并受益 项目和研究人员，并培育新的有价值的临床研究 项目。核心是在南加州大学学院的塔霍尔诊所 医学校园，由项目主任施奈德博士， 老年医生，双语临床心理学家，一项研究 护士/协调员、行政助理和研究助理。 具体目标包括试行或初步临床的表现 检验新假说的药理学研究；增强 招募少数民族受试者进行临床调查； 对行为症状的治疗进行对照研究 阿尔茨海默氏症；规划和开发未来的药理学 工作。该堆芯自1992年9月才开始运行。 目前的目标是：进一步发展行政结构 为有效协调和发展临床药理研究， 涉及全面的文档、患者评估、评估 评估方法和结果的有效性和可靠性；以及 对以前和现在的研究对象提供长期跟踪 促进各种治疗方法的临床研究和评估 以及针对AD患者的治疗和管理的干预措施， 包括试点、I期和II期临床评价； 药代动力学的表征，包括设计和 实施剂量递增和安全性研究；加强 招募少数民族受试者进入ADRC的药理学核心 临床核心，西班牙语节目，以及卫星节目： 进行认知和行为主动性的初步研究 有症状行为的AD患者的药物治疗，如激越， 精神病和严重抑郁症；提供咨询和教育 研究药物资源与临床药理学 向ADRC的其他组成部分、社区提供AD；并与 其他ADRC临床和基础研究项目，用于收购 研究样本和措施。

ADRC Subcore in Clinical Pharmacology. The clinical neuropharmacology subcore for the Alzheimer's Disease Research Center Consortium of Los Angeles and Orange Counties (ADRC) maintains an infrastructure to support, strengthen, and facilitate clinical pharmacological research in the ADRC. The core improves the quality of clinical research and hypothesis testing; increases the kinds of clinical studies performed; and increases and expedites patient access to studies at the ADRC. The resources of the core are utilized by and benefit individual ongoing projects and investigators and foster new meritorious clinical research projects. The core is based at the Tower Hall Clinical on the USC School of Medicine campus, and consists of a program director, Dr. Schneider, geriatric physicians, a bilingual clinical psychologist, a research nurse/coordinator, and administrative assistant, and research assistants. Specific goals include the performance of pilot or preliminary clinical pharmacological investigations to test new hypotheses; enhancement of recruitment of ethnic minority subjects to clinical investigations; conducting controlled studies of treatments for behavioral symptoms in Alzheimer's dementia; planning and developing future pharmacological work. The core has been in operation only since September, 1992. Current objectives are: To further develop the administrative structure to efficiently coordinate and develop clinical pharmacological research, involving comprehensive documentation, evaluation of patients, assessing the validity and reliability of evaluation methods and results; and providing long-term follow-up of former and current research subjects to facilitate clinical investigations and evaluation of various therapies and interventions directed toward treatment an management of AD patients, including pilot, phase I and phase II clinical evaluations; characterization of the pharmacokinetics, including the design and implementation of dose escalation and safety studies; to enhance recruitment of ethnic-minority subjects to the pharmacology core, ADRC Clinical Core, Spanish-speaking program, and to the satellite program: to undertake pilot studies of both cognitively and behavioral active medications in AD patients with symptomatic behaviors such as agitation, psychosis and major depression; to provide consultative and educational resources on investigational medications and the clinical pharmacology of AD to other ADRC components, to the community; and to cooperate with other ADRC clinical and basic research programs in the acquisition of research specimens and measures.