PILOT STUDIES

本构成部分描述支持和管理Pilot的计划 项目，包括科学和技术审查程序。这个 康涅狄格州大学ARC成功地使用了一个非正式的试点项目计划 过去开发新的研究倡议，符合 中心。以前部分由该计划资助的项目包括 为初级保健机构设计筛查仪器的研究 电生理学研究--医患配对方案 易损性因素，以及两项公开的新药理试验 干预措施。这些活动对以下方面做出了重大贡献 该中心的研究项目。 本申请中提出的试点研究计划将由 执行委员会和科学咨询小组。正式 书面申请必须包括科学的理由，详细的 研究计划和预算。申请将由两个人审查 适当的外部审查员(包括中心的成员 科学咨询小组)。关于为飞行员提供资金的决定 研究申请将由科学主任和 执行委员会。 本申请中描述的五个项目代表 以前得到支持并与 中心的主要专题领域。这些项目包括一个 COS细胞氯离子通量的分子生物学研究 应用SPECT和MR成像方法研究苯二氮卓类受体 酒精(与成分23相关)，D2 A1的关联研究 酗酒者及其未受影响同胞的等位基因频率(与 成分21)，以及使用尼莫地平作为辅助剂的研究 苯二氮类药物对酒精戒断的治疗(与成分25有关)。 在接下来的五年里，将向 ARC调查人员和在相关领域工作的同事协助 有前途的想法和新技术的发展。

This component describes plans for the support and management of pilot projects, including procedures for scientific and technical review. The UCONN ARC has successfully used an informal pilot project program in the past to develop new research initiatives consistent with the theme of the Center. Previous projects funded, in part, from this program include a study to devise a screening instrument for primary care settings, a patient-treatment matching project, a study of electrophysiological vulnerability factors, and two open trials of new pharmacological interventions. These activities have made significant contributions to the Center's research programs. The pilot study program proposed in this application will be managed by the Executive Committee and the Scientific Advisory group. Formal written applications must include a scientific rationale, a detailed research plan and a budget. Applications will be reviewed by two appropriate outside reviewers (including members of the Center's Scientific Advisory Group). Decisions regarding the funding of pilot study applications will be made by the Scientific Director and the Executive Committee. The five projects described in this application are representative of the kinds of preliminary research previously supported and are linked to the major thematic areas of the Center. The projects include an investigation of the molecular biology of chloride flux in COS cells, the use of SPECT and MR imaging methods to study benzodiazepine receptors in alcoholics (linked to Component 23), an association study of the D2 A1 allele frequency in alcoholics and their unaffected sibs (linked to Component 21), and a study of the use of nimodipine as an adjunct to benzodiazepine treatment of alcohol withdrawal (linked to Component 25). Over the next five years additional applications will be solicited from ARC investigators and colleagues working in related areas to assist in the development of promising ideas and new technologies.