CORE--GERIATRIC PSYCHOPHARMACOLOGY

老年精神药理学实验室拟开展的活动 是从儿童权利中心在这方面正在进行的研究和从 宾夕法尼亚大学项目的长期兴趣是精神药理学。这个 实验室的设计旨在提供一种结构，以便于 两种药物治疗晚期精神障碍的研究 用于治疗医疗疾病的药物的生命和精神影响； 它提供基础设施支持，以开发新的研究并支持 初级侦查员的发展。这篇文章中描述的研究 申请由两项研究组成，即去甲替林治疗 《养老院老人中的抑郁症》和《妄想症： 对老年人急性认知变化的监测研究进展 通过儿童权利委员会倡议，现在是独立资助的，以及两个 新项目“舍曲林的安全性和有效性的初步研究 心肌梗死后的抑郁“和”刺激性反应 老年性抑郁症：治疗和探索“。舍曲林研究是 之所以提出，是因为使用该药物观察到的不良事件情况 因此，它现在可能第一次有可能进行更大规模的 心肌梗死后抑郁治疗的量表对照研究 患者评估治疗的功能结果以及 症状的减少；然而，在这样的研究可以进行之前， 有必要确认舍曲林的安全性，特别是在心肌梗塞后 病人。这项兴奋剂研究是一项安慰剂对照研究 哌醋甲酯治疗住院康复中的抑郁症 设置，其中响应的快速性对于克服 抑郁症对康复进程的阻碍作用；它是 也旨在开发刺激性挑战，作为异质性的测试 在老年患者情绪调节的胺能系统中 患有慢性病。

The proposed activities of the Laboratory of Geriatric Psychopharmacology are derived from both the CRC's ongoing studies in this area and from the longstanding interests of Penn's program m psychopharmacology. The Laboratory is designed to provide a structure that will facilitate research on both the drug treatment of the psychiatric disorders of late life and the psychiatric effects of drugs used to treat medical disorders; it provides infrastructure support to develop new research and to support the development of junior investigators. The research described in this application consists of two studies, "Nortriptyline Treatment of Depression in the Nursing Home Aged", and "Delirium Reconsidered: Monitoring for Acute Cognitive Change in the Elderly" that were developed through CRC initiatives and are now independently funded as well as two new projects, "A Pilot Study of the Safety and Efficacy of Sertraline in Depression after Myocardial Infarction ", and "Stimulant Responses in Geriatric Depression: Treatment and Probe". The Sertraline study is proposed because the profile of adverse events observed with this agent is such that it may now, for the first time, be possible to conduct larger scale controlled studies of the treatment of depression in post-mi patients to assess the functional outcome of treatment as well as the reduction in symptoms; however, before such research can be conducted it is necessary to confirm the safety of sertraline specifically in post-mi patients. The Stimulant study is a placebo-controlled study of methylphenidate treatment for depression in the inpatient rehabilitation setting, where rapidity of response can be important to overcome the effects of depression as a barrier to the process of rehabilitation; it is also designed to develop stimulant challenges as tests for heterogeneity in aminergic systems underlying the regulation of affect in older patients with chronic disease.