CHRONIC COCAINE EXPOSURE DURING GESTATION:PRENATAL

这个项目的目标是研究一种非人类的 灵长类动物模型产前暴露可卡因的影响 更好地了解与使用可卡因有关的风险 怀孕了。临床报告表明，越来越多的人 入院时可卡因检测呈阳性的孕妇 在分娩期间，这些妇女和她们的新生儿在医院 增加了一些异常情况的风险。然而，直接的 可卡因对妊娠结局的影响很难确定 因为有许多令人困惑的因素。这个项目是 在恒河猴身上研究可卡因的使用后果 在怀孕期间，为了描述对怀孕的影响 雌性，发育中的胎儿和由此产生的后代 受控实验室环境的直接贡献 可卡因可以被检测出来。在过去的一年里，接触可卡因 对青少年及其配对喂养对照进行S多项指标的测试 认知和记忆，以及对药物破坏的敏感性 对行为表现进行测定。此外，相当大的 人们一直致力于静脉注射药物的开发 自主管理协议。血管通路提供了一种 静脉注射可卡因的有效手段，以及一组 受试者已经接受了训练，以执行一项行为任务，这会导致 可卡因外卖。获取速度，对各种不同的敏感性 可卡因的剂量和对药物拮抗的敏感性 可卡因的强化作用将决定产前接触可卡因 吸食可卡因会产生长期后果，可能会影响 在成年后滥用可卡因。

The objectives of this project are to investigate in a nonhuman primate model the effects of prenatal cocaine exposure in order to understand better the risks associated with cocaine use during pregnancy. Clinical reports have indicated that an increasing number of pregnant women test positive for cocaine when admitted to the hospital during labor, and that these women and their newborns are at increased risk for a number of abnormalities. However, the direct effects of cocaine on pregnancy outcome are difficult to ascertain in humans because of a number of confounding factors. This project is studying in rhesus monkeys the consequences of cocaine administration during gestation in order to characterize effects on the pregnant female, the developing fetus and the resulting offspring in a controlled laboratory environment where the direct contribution of cocaine can be determined. During the past year, cocaine-exposed juveniles and their pair-fed controls were tested on s everal measures of cognition and memory, and sensitivity to pharmacological disruption of behavioral performances was determined. In addition, considerable effort has been directed toward the development of intravenous drug self-administration protocols. Vascular access ports have provided an effective means to administer cocaine intravenously, and a group of subjects has been trained to perform a behavioral task that results in cocaine delivery. The rate of acquisition, sensitivity to various doses of cocaine, and susceptibility to pharmacological antagonism of cocaine's reinforcing effects will determine whether prenatal exposure to cocaine has long-term consequences that can affect the likelihood of cocaine abuse in adulthood.