MODEL OF HANTA PULMONARY SYNDROME USING HANTA SIN NOMBRE VIRUS

1993年夏天，在这四个人中发现了一种新的综合征 美国角落地区，由一种以前不为人知的 本雅氏病毒(Hanta Sin Norbre)。虽然病毒在系统中被发现 死于感染的患者，肺的发病机制 仍有待阐明。在这个程度上，6只恒河猴被 经鼻腔或静脉感染HSNV。所有动物都没有表现出 临床症状和病毒负担仍然很低，甚至检测不到。这个 然而，动物的反应是抗体效价、低水平的IFNK和 病毒特异性细胞介导的反应。的性质和规模 这些答复目前正在评估中，并将进行比较 与在人类患者身上获得的值一致。

During summer of 1993, a novel syndrome was identified in the Four Corners area of the United States, caused by a previously unknown bunyavirus (Hanta sin nombre). While virus is found systemically in patients that died from the infection, the pulmonary pathogenesis remains to be elucidated. To that extent, 6 rhesus macaques were infected with HSNV either intranasally or iv. All animals showed no clinical symptoms and viral burdens remained low to undetectable. The animals responded however with antibody titers, low levels of IFNK and virus specific cell mediated responses. The nature and magnitude of these responses are currently being evaluated and will be compared with values obtained on human patients.