ANALYSIS, BIOLOGY, CORRECTION OF CRANIOFACIAL DISORDERS

我们建议建立一个口腔健康综合研究中心。 发现(COHRCD)，重点是分析、生物学和纠正 头面部畸形。该中心将涉及以下努力 宾夕法尼亚大学(U Of P)中心内的几个实体 为医疗保健科学服务。这些实体包括 费城儿童医院牙科医学(教学 P大学医学院)，伦纳德·戴维斯研究所 以及其他将从共享中受益的协作组织 专业知识和研究成果。建议的基本目标是 计划的目的是促进更多的了解、信息共享和 交流颅面发育领域的研究成果 以及与遗传性疾病有关的骨生物学。我们的工作目标 是利用现有的、广泛的临床和基础科学 与北卡罗来纳大学和我们的COHRCD研究主题有关的专业知识 地区同事。在COHRCD中，来自不同国家的调查人员 将为学科提供框架，以便在其中共享 资源和交换信息，涉及以下多个方面 正常和异常的颅面形态发生。为了发展这一点 中心，我们建议启动一个规划过程。此规划阶段 将使我们能够开发基础设施并确保 对未来区域中心的机构间承诺 太棒了。因此，我们将： 1.整合生物医学、行为科学、社会科学和健康 合作机构的服务研究基地。 2.制定一个示范研究部分，其中将包括外联活动 和社区联络职能。 3.制定涉及健康教育的研究计划 专业人士和科学家以及由 合作机构。 4.开发技术转让组成部分，以促进和 加快落实该中心取得的进展。 5.创建强大的行政和研究支持核心，以 提供协调中心活动的结构和 确保资源的高效利用。 建立一个中心，重点是了解人的生物学 颅面畸形将导致这一规划领域的进展。 这些进展将被用来开发新的、更强大的诊断 和纠正措施，将适用于儿科和 成年人口。

We propose to develop a Comprehensive Oral Health Research Center of Discovery (COHRCD) with a focus on the analysis, biology and correction of craniofacial abnormalities. This Center will involve the efforts of several entities within the University of Pennsylvania (U of P) Center for the Health Care Sciences. These entities include the School of Dental Medicine, the Children's Hospital of Philadelphia (a teaching hospital of the U of P School of Medicine), the Leonard Davis Institute and other collaborative organizations that will benefit by sharing expertise and research results. The fundamental goal of the proposed program is to facilitate greater understanding, information sharing and exchange of research findings in the areas of craniofacial development and bone biology as related to heritable diseases. Our working objective is to capitalize on the existing, extensive clinical and basic science expertise related to the COHRCD research theme at the U of P and of our regional colleagues. In the COHRCD, investigators from different disciplines will be provided with the framework within which to share resources and exchange information pertaining to multiple aspects of normal and abnormal craniofacial morphogenesis. In order to develop this center, we propose to initiate a planning process. This planning phase will allow us to develop the infrastructure and secure interinstitutional commitments for the future regional Center of Excellence. Thus, we will: 1. Integrate the biomedical, behavioral, social science and health services research bases of the collaborating institutions. 2. Develop a demonstration research component that will include outreach and community liaison functions. 3. Develop a research program that involves education of health professionals and scientists as well as the communities served by the collaborating institutions. 4. Develop a technology transfer component that will facilitate and hasten the implementation of advances made in the Center. 5. Create strong administrative and research support cores that will provide the structure for coordinating the activities of the Center and ensuring efficient use of resources. Establishing a center with a focus in understanding the biology of craniofacial anomalies will lead to advances in this programmatic area. These advances will be used to develop new and more powerful diagnostic and corrective measures which will be applicable to both pediatric and adult populations.