MATURATIONAL ROLES OF GONADOTROPIN RELEASING HORMONE (GNRH) PULSE FREQUENCY

本研究的目的是探讨在我国， 中枢神经系统对性生活中促性腺激素分泌的控制 人类的成熟。 拟议的研究是基于 促性腺激素释放激素脉冲频率 在人类性成熟和整个生殖过程中起着调节作用。 月经周期 具体而言，我们建议评估 主要的性类固醇，睾酮（T）和雌二醇（E[2]）， 促性腺激素释放激素的分泌。 我们亦建议研究是否有需要，以及如果有需要， 当内源性阿片途径参与调节时， 人类性成熟过程中GnRH的分泌。

The purpose of this research is to investigate the changes in the central nervous system control of gonadotropin secretion during sexual maturation of human beings. The proposed studies are based on the hypothesis that gonadotropin-releasing hormone (GnRH) pulse frequency plays a regulatory role in human sexual maturation and throughout the menstrual cycle. Specifically, we have proposed to evaluate the effects of the principal sex steroids, testosterone (T) and estradiol (E[2]), on GnRH secretion. We have also proposed to examine whether, and if so when, endogenous opioid pathways become involved in the regulation of GnRH secretion during human sexual maturation.