ETHNICITY, BODY COMPOSITION, BONE DEN AND BREAST CANCER

描述：（改编自申请人摘要）。 最近，两项研究 报告了高骨量和增加的风险之间的强相关性， 乳腺癌 申请人称，这一结果提出了新的问题， 在HRT的决策，并建议潜在的使用骨量作为一个 乳腺癌危险性评价指标雌激素暴露。 对不同种族群体的进一步研究似乎是必要的，因为 有显着的种族差异的频率，分布和 骨质疏松症和乳腺癌的严重程度。 考虑到 骨矿物质密度（BMD）较高，但乳腺癌的发病率较高， 西班牙裔老年妇女比盎格鲁妇女低， 绝经后妇女将是一个模型，以进一步评估的关系， 乳腺癌和骨质疏松之间的联系 迄今为止，大多数风险知识 骨质疏松症和乳腺癌的因素主要是基于结果， 英国女人 在西班牙裔中检查这些风险因素至关重要 为了制定具体的预防战略， 人口 妇女健康倡议（WHI）提供了一个独特的 进行巢式病例对照研究（NCCS）的机会， 在不同的种族群体中研究这些问题。 然而，在WHI中， 没有足够的乳腺癌病例来组成NCCS 在西班牙裔女性中，这两个原因都是因为WHI BMD中西班牙裔女性的数量 研究队列较小（预期n=800），因为乳腺癌发病率 西班牙裔女性比盎格鲁裔女性更低。 拟议的研究是一项 病例对照研究设计。 对照组将从西班牙裔中选出 亚利桑那州WHI观察研究小组的参与者。 没有附加数据 将从对照组中收集。 病例（n=140）将是新的 亚利桑那州的西班牙裔绝经后乳腺癌患者 （通过肿瘤学家和外科医生合作获得）。 测量 将包括人体测量、身体成分、BMD、外周白色血 细胞和WHI问卷。 骨密度与乳腺癌的关系 将使用逻辑回归分析来评估癌症。 注：NIA为申请人提供基本上未经编辑的评论 由审查委员会成员编写。 所附评注可 包含不同或冲突的观点。 值得注意的是， 在审查会议之前准备好，可能是，也可能不是 更新以反映委员会的讨论。 然而，建议和 本简要说明的其他开头部分具有权威性， 代表小组讨论的最终结果。

DESCRIPTION: (Adapted from applicant's abstract). Recently two studies reported a strong association between high bone mass and increased risk of breast cancer. According to the applicant, this result raises new questions in decision-making for HRT and suggests a potential use of bone mass as an indicator of lifetime estrogen exposure for assessing risk of breast cancer. Additional studies in different ethnic groups appear warranted, because there is significant ethnic variation in frequencies, distributions and severity levels of both osteoporosis and breast cancer. Given the fact that the bone mineral density (BMD) is higher, but the rate of breast cancer is lower in Hispanic older women compared with Anglo women, the Hispanic postmenopausal women would be a model to further evaluate the relationship between breast cancer and bone mass. To date, most knowledge of risk factors of osteoporosis and breast cancer is mainly based on results from Anglo women. It is critical to examine those risk factors in the Hispanic population in order to form specific prevention strategies for this population. The Women's Health Initiative (WHI) provides a unique opportunity to undertake nested case-control studies (NCCS) to further examine these issues in different ethnic groups. However, within the WHI there will not be a sufficient number of breast cancer cases to form a NCCS in Hispanic women, both because the number of Hispanic women in the WHI BMD study cohorts is small (expected n=800) and because breast cancer rate is lower in Hispanic women compared with Anglo. The proposed study is a case-control research design. The controls will be chosen from the Hispanic participants of the Arizona WHI observation study group. No additional data will be collected from the controls. The case (n=140) will be newly diagnosed Hispanic postmenopausal breast cancer patients in Arizona (obtained through collaborative oncologists and surgeons). Measurements will include anthropometry, body composition, BMD, peripheral white blood cells and WHI questionnaires. The relationship between BMD and breast cancer will be evaluated using logistic regression analysis. Note: NIA is providing applicants with essentially unedited commentaries prepared by members of the review committee. The attached commentaries may contain divergent or conflicting views. It should be noted that critiques were prepared prior to the review meeting and they may or may not have been updated to reflect committee discussion. However, the recommendation and other initial sections of this summary statement are the authoritative representation of the final outcome of group discussion.