CORE--CANCER SURVEILLANCE PROGRAM

描述（申请人的描述）：癌症监测计划（CSP）是洛杉矶县基于人群的快速确定癌症登记。 本计划项目资助申请中描述的所有三个项目，以及一系列单独资助的分析流行病学研究，都依赖于CSP进行快速病例识别。 自1987年以来，CSP日常活动的大部分资金来自加州州，通过加州癌症登记处（CCR）。 CSP是CCR的十个区域登记册之一，这些登记册共同提供了对国家的完整覆盖。 1992年，CSP成为美国国家癌症研究所监测、流行病学和最终结果（SEER）合作登记中最新和最大的一个。 本申请所要求的资金将用于支持CSP的快速确定部分，所有三个项目都将使用该部分。 CSP还提供了关于癌症变化模式的演示图形细节，这些细节在为医源性假设提供线索方面被证明是非常宝贵的。 它设有一个追踪实验室，用于追踪流行的癌症患者，项目C也将利用该实验室。CSP的主要重点一直是并将继续是病原学研究。 CSP的主要特点包括：（1）人口基数的规模和多样性;（2）主动和被动监测;以及（3）快速确定病例。 后一个功能是CSP的高度优先事项。 RCA的活动包括通过在诊断出癌症的所有设施定期检查病理报告来查明所有新病例。 对于符合正在进行的研究的患者报告（目前每年总计约13，100份报告），CSP现场技术人员提取了最小数据集。 患有可能迅速致命疾病的病人，会在确诊当日以传真方式向社区支援服务办事处呈报，以进一步加快确诊的速度。 从病理学日期到病理学报告交付给研究者日期的平均间隔为4周。

DESCRIPTION (Applicant's Description): The Cancer Surveillance Program (CSP) is the rapid ascertainment population-based cancer registry for Los Angeles County. All three projects described in this Program Project Grant application, as well as a series of separately funded analytic epidemiologic studies, depend on the CSP for rapid case identification. Since 1987, the majority of funding for the day-to-day activities of the CSP has come from the State of California, through the California Cancer Registry (CCR). The CSP is one of ten regional registries of the CCR, which together provide complete coverage of the State. In 1992, the CSP became the newest and largest of the National Cancer Institute's Surveillance, Epidemiology and End Results (SEER) collaboration of registries. Funds requested by this application will support the rapid ascertainment (RCA) component of the CSP, which will be utilized by all three projects. The CSP also provides demo graphic details on changing patterns of cancer which have proven invaluable in providing clues to iatrogenic hypotheses. It maintains a tracing laboratory for tracing prevalent cancer patients which will also be utilized by Project C. The major focus of the CSP has always been and will continue to be etiologic research. The major distinctive features of the CSP include (1) the size and diversity of the population base; (2) both active and passive surveillance; and (3) rapidity of case ascertainment. The latter feature is a high priority of the CSP. RCA activities include the identification of all new cases through regular screening of pathology reports at all facilities where cancer is diagnosed. For patient reports qualifying for ongoing studies (currently totaling about 13,100 reports annually) a minimal data set is abstracted by CSP Field Technicians. Patients with potentially rapidly fatal diseases are reported by fax to the CSP office on the day of ascertainment to further enhance rapidity of ascertain ment. The average interval from date of pathology to the date that the pathology report is delivered to the study investigator is four weeks.