PHASE I TRIAL OF MINOCYCLINE IN PATIENTS WITH CANCER

本研究的目的是确定增加米诺环素剂量的副作用，并确定患者可以耐受的米诺环素的最大剂量。 这项研究还将评估米诺环素离开患者体内需要多长时间。 米诺环素是一种抗生素，由食品和药物管理局批准用于治疗某些感染。 新的研究表明，它有能力抑制癌细胞中某些酶的活性，这些酶对肿瘤细胞的生长和扩散很重要。 这些结果表明，米诺环素可能有助于患者的身体停止或防止患者癌症的进一步生长。

The purpose of this research study is to determine the side effects of increasing doses of minocycline and to determine the maximum dose of minocycline that patients can tolerate. This study will also assess how long it takes for minocycline to leave the patients body. Minocycline is an antibiotic which is approved by the Food and Drug Administration for the treatment of certain infections. New research has revealed that it has the ability to inhibit the activity of certain enzymes in cancer cells which are important in allowing tumor cells to grow and spread. These results suggest that minocycline may help the patients body to stop or prevent the further growth of the patients cancer.