DFCI-BIDMC-CH CENTER FOR AIDS RESEARCH

本申请建议建立Dana-Farber癌症研究所、以色列女执事医学中心和儿童医院(DFCI-BIDMC-CH)艾滋病研究中心(DFCI-BIDMC-CH CFAR)。DFCI-BIDMC-CH CFAR包括在达纳-法伯癌症研究所、贝丝以色列女执事医学中心和儿童医院进行的临床和基础科学研究。DFCI-BIDMC-CH CFAR是这些机构对艾滋病研究和患者护理的长期承诺的产物，并建立在达纳-法伯研究所现有的艾滋病研究中心的基础上。CFAR奖将支持继续或建立六个科学核心设施。行政核心为：1)CFAR领导层，包括执行委员会和五个咨询委员会；2)发展和临床核心；3)核心设施；以及4)CFAR成员。开发核心将被用来加强CFAR研究计划，为新的调查人员开发与艾滋病相关的研究活动提供支持，并为利用艾滋病研究的创新想法和技术的试点项目提供支持。生物危害遏制核心为CFAR调查人员的跨学科团队提供了一个Biosaftey Level 3设施，用于繁殖和纯化人类或猿类免疫缺陷病毒。动物生物危险控制(ABC)核心设施的目的是为需要生物安全2级或3级控制的艾滋病相关小鼠工作提供支持。分子生物学核心设施在收费的基础上提供寡核苷酸和结合或非结合多肽。该细胞培养设施的设计是为了向研究人员提供大量的单克隆抗体和纯化的蛋白质，以用于艾滋病相关研究。临床核心的主要重点是在CFAR成员机构和周围社区开展艾滋病临床研究。生物统计核心支持在整个CFAR中就定量方法向调查人员进行咨询和合作。

OVERALL DESCRIPTION (adapted from the application): This application proposes the establishment of the Dana-Farber Cancer Institute Beth Israel Deaconess Medical Center, and Children's Hospital (DFCI-BIDMC-CH) Center for AIDS Research (DFCI-BIDMC-CH CFAR). The DFCI-BIDMC-CH CFAR encompasses clinical and basic science research conducted at the Dana-Farber Cancer Institute Beth Israel Deaconess Medical Center, and Children's Hospital. The DFCI-BIDMC-CH CFAR is the product of the longstanding commitment of these institutions to AIDS research and patient care, and builds upon an existing Center for AIDS Research at the Dana-Farber Institute. The CFAR award would support the continuation or establishment of six scientific Core Facilities. The Administrative Core provides administrative support to: 1) the CFAR leadership, including the Executive Committee and five advisory committees; 2) the Development and Clinical Cores; 3) the Core Facilities; and 4) the CFAR membership. The Development Core will be utilized to enhance the CFAR research program by providing support for new investigators to develop AIDS-related research activities and for pilot projects to exploit innovative ideas and technology for AIDS research. The Biohazard Containment Core provides a Biosaftey Level 3 facility for the propagation and purification of human or simian immunodeficiency viruses for the interdisciplinary team of CFAR investigators. The purpose of the Animal Biohazaard Containment (ABC) Core Facility is to provide support for AIDS-related mouse work that requires biosafety levels 2 or 3 containment. The Molecular Biology Core Facility provides oligonucleotides and conjugated or unconjugated peptides on a charge-back basis. The cell culture facility is designed to provide large amounts of monoclonal antibodies and purified proteins to researchers for the use in AIDS related research. The major emphasis of the Clinical Core is to develop clinical AIDS research in the CFAR member institutions and the surrounding community. The Biostatistics Core supports consultation and collaboration on quantitative methods to investigators throughout the CFAR.