CLINICAL RESEARCH CENTER FOR OPIOID AND COCAINE ABUSE

此次五年制中心续期以我们的神经生物学主题为基础 前九年通过检查病理生理学和治疗 可卡因和艾滋病的神经毒性。该中心的项目范围从临床前到 与阿片类药物相关的人类实验室和临床试验的神经生物学 和可卡因依赖，以及艾滋病毒感染。在过去的5年中 我们有50多种出版物，10项独立的新赠款，以及大量的 所有7个项目的进展情况。我们现在制定了六个新的重大项目 本中心续建其中四个项目均为以往项目的延伸：1. 可卡因对HPA轴和神经行为的影响，2.糖皮质激素 在可卡因依赖中的作用，3.SPECT和微透析测量 可卡因滥用，4，拉莫三嗪，针对HIV+患者的可卡因滥用。两个新的 项目是从我们的试点工作和与 全科医学临床研究中心和艾滋病临床试验单位 耶鲁大学：5.阿米洛利治疗可卡因相关性脑灌注缺陷， 6.阿片依赖药物治疗对艾滋病的抗病毒作用 药物。核心将继续支持与这些公司的协作 耶鲁大学的其他研究中心将整合到该中心的主要领域 项目和调查人员，并每年进行2-3项试点研究 专注于艾滋病相关治疗和神经生物学。这些飞行员包括 美沙酮和美沙酮对早期艾滋病患者皮质醇水平的影响 艾滋病患者认知功能障碍的神经影像研究

This five year Center renewal builds on the neurobiology THEME of our previous nine years by examining the pathophysiology and treatment of cocaine and AIDS neurotoxicity. The Center projects range from preclinical neurobiology to human laboratory and clinical trials relevant to opioids and cocaine dependence, as well as HIV infection. During the last 5 years we have over 50 publications, 10 independent new grants, and substantial progress on all 7 projects. We now developed six new Major Projects for this Center renewal of which four are extensions of previous projects: 1. The HPA Axis and Neurobehavioral Effects of Cocaine, 2. Glucocorticoid Function in Cocaine Dependence, 3. SPECT and Microdialysis Measurements of Cocaine Abuse, 4,Lamotrigine for Cocaine Abuse in HIV+Patients. Two new projects have evolved from our pilot work and collaborations with both the General Medical Clinical Research Center and the AIDS Clinical Trials Unit at Yale: 5. Amiloride for Cocaine Associated Cerebral Perfusion Deficits, 6. Opiate Dependence Pharmacotherapy Effects on AIDS Antiviral medications. The CORE will continue to support collaborations with these other research Centers at Yale, to integrate across the Center's Major Projects and investigators, and to conduct 2-3 pilot studies per year with a focus on AIDS related treatments and neurobiology. These pilots include cortisol levels in early AIDS patients on methadone treatment and neuroimaging in AIDS patients with cognitive impairment.