PRESCRIPTIVE THERAPY FOR DRUG ABUSE WITH DEPRESSION

描述：（申请人摘要） 可卡因滥用代表了美国社会中一个严重且日益严重的问题。 需要有效的治疗方法，既解决吸毒问题， 滥用，并充分解决伴随和经常观察到的 抑郁症在这个群体中 第一阶段的研究计划是初步的 进行大规模随机临床试验比较的步骤 选择性地结合几种有效的治疗方法， 不同的治疗方法。 具体而言，处方治疗（PT） 使用受试者的痛苦水平，外化应对方式和阻力 倾向于个性化治疗和指导选择 来自支持性咨询、认知疗法和 实验治疗模型。 为了进行更大规模的研究，PT将 与两种手动治疗，认知疗法， (CT)和支持/自我导向治疗（S/SD），通过四个预备 阶段。 在第一阶段，我们将选择工具并完善 应用处方疗法和对比干预。 同相 2，我们将测试程序，选择和培训治疗师在 三种治疗方法。 在第三阶段，我们将选择一个病人样本， 表现为可卡因滥用和轻度至中度烦躁不安， 抑郁谱 这一阶段将用于回答主题的问题 以及挑选参加者， 目前项目的最后阶段。 在第四阶段，我们将对 能够提供改良的PT、CT和S/SD治疗以治疗合并症， 可卡因滥用和抑郁症患者

DESCRIPTION: (Applicant's Abstract) Cocaine abuse represents a serious and growing problem in American society. Effective treatments are needed that both address problems of drug use and abuse and that adequately address concomitant and frequently observed depression in this group. This stage 1 research proposal is a preliminary step toward conducting a large scale, randomized clinical trial comparison of a treatment that selectively combines effective procedures from several different treatment approaches. Specifically, Prescriptive Therapy (PT) uses subject distress level, externalizing coping style, and resistance tendencies to individualize treatment and guide the selection of interventions drawn from supportive counseling, cognitive therapy, and experimental treatment models. In anticipation of the larger study, PT will be refined and contrasted with two manualized treatments, Cognitive Therapy (CT) and Supportive/Self-Directed Therapy (S/SD) through four preparatory phases. In Phase 1, we will select instruments and refine the rules of applying Prescriptive Therapy and the contrasting interventions. In Phase 2, we will test procedures for selecting and training therapists in the three treatment procedures. In Phase 3, we will select a sample of patients presenting with cocaine abuse and mild to moderate dysphoria within the depressive spectrum. This phase will be used to answer questions of subject availability and representativeness as well as to select participants in the final phase of the current project. In Phase 4, we will pilot test the ability to deliver the modified PT, CT, and S/SD treatments to co-morbid, cocaine abusing and depressed patients.