BODY COMPOSITION AND ENERGY REQUIREMENT IN PEDIATRIC HIV INFECTION

尽管大多数感染艾滋病毒的儿童会发展成 生长和营养异常，艾滋病毒对 身体成分和营养需求尚不清楚。 目前，营养治疗通常是经验性的，而不是 始终如一。这项提案的目的是确定 HIV感染儿童的身体成分分析 使用更复杂的技术，并确定 总能量需求和静息能量需求。我们的第一个目标是 使用三种不同的方法对身体隔间进行角色化 方法论。我们有关于皮肤皱纹的初步数据 对感染艾滋病毒的儿童进行测量。我们会比较一下 传统人体测量法的测量结果 氚同位素稀释法获得的测量结果(至 测量全身水分)和生物电阻抗 分析。后两种方法还没有在 感染艾滋病毒的儿童。这方面的第二个目标 该项目是研究能源需求的一个小项目 感染艾滋病毒的儿童和对照人数，分层 根据疾病预防控制中心的分类(疾病的标志 严重性)。将对三组儿童进行研究， 将接受休息和休息的同时评估 使用间接量热法的总能量消耗和 双标记水技术。这一试点项目是 严重依赖于质谱学和 以生物统计学为核心。我们希望所获得的信息 通过这一试点项目将改善临床护理和 艾滋病病毒感染者的营养康复计划 并将作为理性的基础 营养干预方案。

Although most children with HIV infection will develop growth and nutritional abnormalities, the effects of HIV on body composition nd nutritional requirements are not known. Currently, nutritional therapy is often empiric and not consistent. The aims of this proposal are to determine the components of body composition in the HIV-infected child with more sophisticated techniques and to determine both total and resting energy requirements. Our first goal is to characterize the body compartments using three different methodologies. We have preliminary data on skin fold measurements of HIV-infected children. We will compare measurements from traditional anthropometry with measurements obtained by deuterium isotope dilution (to measure total body water) and bioelectrical impedance analysis. The latter two methods have not been employed in children with HIV infection. The second goal of this project is to study the energy requirements of a small number of HIV infected children and controls, stratified according to CDC classification (a marker of disease severity). Three groups of children will be studied and will undergo simultaneous assessments of both resting and total energy expenditure using indirect calorimetry and the doubly labelled water technique. This pilot project is heavily dependent on the Mass Spectrometry and Biostatistics Cores. We expect that information obtained through this pilot project will improve clinical care and nutritional rehabilitation programs of HIV-infected children and will serve as the basis for rational nutritional intervention protocols.